A0A849AZM7 · A0A849AZM7_9GAMM
- ProteinRibonuclease H
- GenednaQ
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids470 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Catalytic activity
- DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Mg2+ ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 3'-5' exonuclease activity | |
Molecular Function | DNA binding | |
Molecular Function | DNA-directed DNA polymerase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | RNA-DNA hybrid ribonuclease activity | |
Biological Process | DNA replication proofreading | |
Biological Process | RNA catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibonuclease H
- EC number
- Short namesRNase H
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter > Acinetobacter Taxon 24 > Acinetobacter Taxon 24D
Accessions
- Primary accessionA0A849AZM7
Proteomes
Subcellular Location
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-137 | RNase H type-1 | ||||
Sequence: MTQTITLYVDGACRGNPGLGGWGAYVITETEKHKLYGGVPETTNNRMELTAAIEGIKSCPTDAKLIIWTDSNYVKQGITEWIHGWKKKNWKDVKNPDLWKLLDATCQGREIEWNWIRGHSGHPGNEMADQLANLGAD | ||||||
Coiled coil | 184-211 | |||||
Sequence: VQDDTEALENLAQEMIQSEEMNDEAEVQ |
Sequence similarities
Belongs to the RNase H family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length470
- Mass (Da)52,883
- Last updated2021-09-29 v1
- ChecksumF957C180FA75DE7E