A0A849AZM7 · A0A849AZM7_9GAMM

Function

function

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site10Mg2+ 2 (UniProtKB | ChEBI)
Binding site10Mg2+ 1 (UniProtKB | ChEBI)
Binding site48Mg2+ 1 (UniProtKB | ChEBI)
Binding site70Mg2+ 1 (UniProtKB | ChEBI)
Binding site129Mg2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function3'-5' exonuclease activity
Molecular FunctionDNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionmagnesium ion binding
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Biological ProcessDNA replication proofreading
Biological ProcessRNA catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease H
  • EC number
  • Short names
    RNase H

Gene names

    • Name
      dnaQ
    • Synonyms
      rnhA
    • ORF names
      HLH16_05705

Organism names

  • Taxonomic identifier
  • Strain
    • ANC 5378
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter > Acinetobacter Taxon 24 > Acinetobacter Taxon 24D

Accessions

  • Primary accession
    A0A849AZM7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain, coiled coil.

TypeIDPosition(s)Description
Domain1-137RNase H type-1
Coiled coil184-211

Sequence similarities

Belongs to the RNase H family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    470
  • Mass (Da)
    52,883
  • Last updated
    2021-09-29 v1
  • Checksum
    F957C180FA75DE7E
MTQTITLYVDGACRGNPGLGGWGAYVITETEKHKLYGGVPETTNNRMELTAAIEGIKSCPTDAKLIIWTDSNYVKQGITEWIHGWKKKNWKDVKNPDLWKLLDATCQGREIEWNWIRGHSGHPGNEMADQLANLGADQTLANMKNPSSKAENPLEEAVILDKKKVEKDWLLDDPFGFDLMESDVQDDTEALENLAQEMIQSEEMNDEAEVQDEIVENVAPDLLNVEHPHIVITPRTKQVHGPRQLILDTETTGFYFQDTDRIIEVGAIEMVNRKLTGSSIHIYINPKKPVGDSENIHGISDDFLKDKPVYAEIADVLFEYLKGAEIIAHNATFDMNFLNMEFKRAGFVALSDVCEVTDTLAMAKSKHPGQKNSLDALVRRYEIPQRDRTFHGALLDAEILADVYLAMTGGQVSFDMDTLTESEQQEAQTARLSVQIELPVILPSEQELKAHETWVKEFEEKHGTACLFAK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABERK010000015
EMBL· GenBank· DDBJ
NNG81481.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp