A0A847WH67 · A0A847WH67_9FIRM
- ProteinMultifunctional fusion protein
- GenearoQ
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids318 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Catalyzes a trans-dehydration via an enolate intermediate.
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Catalytic activity
- 3-dehydroquinate = 3-dehydroshikimate + H2O
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.
Features
Showing features for binding site, site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 13-18 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GSGKTT | ||||||
Binding site | 17 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 35 | substrate | ||||
Sequence: D | ||||||
Binding site | 59 | substrate | ||||
Sequence: R | ||||||
Binding site | 81 | substrate | ||||
Sequence: G | ||||||
Binding site | 119 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 138 | substrate | ||||
Sequence: R | ||||||
Site | 191 | Transition state stabilizer | ||||
Sequence: R | ||||||
Active site | 196 | Proton acceptor | ||||
Sequence: Y | ||||||
Binding site | 248 | substrate | ||||
Sequence: N | ||||||
Binding site | 254 | substrate | ||||
Sequence: H | ||||||
Binding site | 261 | substrate | ||||
Sequence: D | ||||||
Active site | 274 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 275-276 | substrate | ||||
Sequence: LS | ||||||
Binding site | 285 | substrate | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | membrane | |
Molecular Function | 3-dehydroquinate dehydratase activity | |
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | shikimate kinase activity | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process | |
Biological Process | quinate catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMultifunctional fusion protein
Including 2 domains:
- Recommended name3-dehydroquinate dehydratase
- EC number
- Short names3-dehydroquinase
- Alternative names
- Recommended nameShikimate kinase
- EC number
- Short namesSK
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Lachnospirales > Lachnospiraceae > Candidatus Epulonipiscium
Accessions
- Primary accessionA0A847WH67
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 289-309 | Helical | ||||
Sequence: VIAPVCIGQICGFGAMGYLLA |
Keywords
- Cellular component
Interaction
Subunit
Homododecamer.
Monomer.
Structure
Sequence
- Sequence statusComplete
- Length318
- Mass (Da)35,901
- Last updated2021-09-29 v1
- Checksum8B162BFDED3B021F