A0A847WH67 · A0A847WH67_9FIRM

Function

function

Catalyzes a trans-dehydration via an enolate intermediate.
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site13-18ATP (UniProtKB | ChEBI)
Binding site17Mg2+ (UniProtKB | ChEBI)
Binding site35substrate
Binding site59substrate
Binding site81substrate
Binding site119ATP (UniProtKB | ChEBI)
Binding site138substrate
Site191Transition state stabilizer
Active site196Proton acceptor
Binding site248substrate
Binding site254substrate
Binding site261substrate
Active site274Proton donor
Binding site275-276substrate
Binding site285substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Molecular Function3-dehydroquinate dehydratase activity
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionshikimate kinase activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processquinate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    3-dehydroquinate dehydratase
  • EC number
  • Short names
    3-dehydroquinase
  • Alternative names
    • Type II DHQase
  • Recommended name
    Shikimate kinase
  • EC number
  • Short names
    SK

Gene names

    • Name
      aroQ
    • Synonyms
      aroK
    • ORF names
      GX962_08140

Organism names

  • Taxonomic identifier
  • Strain
    • AS23ysBPME_185
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Lachnospirales > Lachnospiraceae > Candidatus Epulonipiscium

Accessions

  • Primary accession
    A0A847WH67

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane289-309Helical

Keywords

Interaction

Subunit

Homododecamer.
Monomer.

Family & Domains

Sequence similarities

Belongs to the shikimate kinase family.
Belongs to the type-II 3-dehydroquinase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    318
  • Mass (Da)
    35,901
  • Last updated
    2021-09-29 v1
  • Checksum
    8B162BFDED3B021F
MRKSNIILIGFMGSGKTTVGKILAKNLHYSFVDSDEEIEKQEQKLIVDIFKEQGETYFRKIEHEMMQKLAQGEKQVIATGGGIIVNKDNISCLKKTGIIIYLKASPNHIYKNVQRDKTRPLLQVENKQKVIADLLAEREGDYLGAADIIISVDGYTPQEIAGQIQENLQRRDSMKEIWVLHGVNLNFLGIREPDIYGDQTLEDINKKICEYGRTKNIQTQFYQSNHEGNLIDQLQKAYYQNVDGIIINPGAFTHYSYGLRDAIASIALPVVEVHLSNIHQRESFRHQSVIAPVCIGQICGFGAMGYLLAIDALNSFIN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAZLH010000167
EMBL· GenBank· DDBJ
NMA83817.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp