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A0A847LUA8 · A0A847LUA8_9SPIR

  • Protein
    Signal recognition particle protein
  • Gene
    ffh
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

144950100150200250300350400
TypeIDPosition(s)Description
Binding site108-115GTP (UniProtKB | ChEBI)
Binding site188-192GTP (UniProtKB | ChEBI)
Binding site246-249GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentsignal recognition particle
Molecular Function7S RNA binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological ProcessSRP-dependent cotranslational protein targeting to membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Signal recognition particle protein
  • EC number
  • Alternative names
    • Fifty-four homolog

Gene names

    • Name
      ffh
    • ORF names
      GX435_04905

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • AS27yjCOA_19
  • Taxonomic lineage
    Bacteria > Spirochaetota > Spirochaetia > Spirochaetales > Exilispira

Accessions

  • Primary accession
    A0A847LUA8

Proteomes

Subcellular Location

Cytoplasm
Note: The SRP-RNC complex is targeted to the cytoplasmic membrane.

Keywords

Interaction

Subunit

Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-86Signal recognition particle SRP54 helical bundle
Domain100-299AAA+ ATPase
Domain101-294SRP54-type proteins GTP-binding

Domain

Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.

Sequence similarities

Belongs to the GTP-binding SRP family. SRP54 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    449
  • Mass (Da)
    50,030
  • Last updated
    2021-09-29 v1
  • MD5 Checksum
    0E0EABEAC2BD4525F668BA3D9C824766
MLESIAKGFDKILSEVFKKGLITESNIKEVLPELKKILIEADVNYEVVDIFLQNVEKKAIGQQITKGVSAREKFIKIVFDELVYFLGEGKKELKIKSKGNRSVILLAGLQGSGKTTTAAKLAKFYKGQKFPLLVAADIYRPAAIEQLQILGAQIGVEVFTQSKKPADKIVKEALNYADSKGLDLVIIDTAGRLQVEKELMDELKLIANVSRPDESLLVVDSMMGQVAAEVAREFTKYIKLSGVILTKFDSDTKGGAALSVKHIANVPIIFSTSGEQLDAIDYFYPDRIAQRMIGMGDILSLVEKAQKQFSEEEAEKLAERLEKSKFDFNDMLTQIEAISKMGGFDSVLQMIPAGQKINQNKVAMQVKRFANYKVIIQSMTKKERNNPLLINNASRRKRIAKGSGTKLIDVLQLMKDYDNMKKMIQKTKGGKINPEMLGLDPETLKNLKL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAYUW010000078
EMBL· GenBank· DDBJ
NLJ05037.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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