A0A847LN70 · A0A847LN70_9SPIR
- ProteinUDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
- GenemurG
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids419 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
Catalytic activity
- di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H+ + UDP
Pathway
Cell wall biogenesis; peptidoglycan biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 14-16 | UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI) | ||||
Sequence: TGG | ||||||
Binding site | 178 | UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 227 | UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 343 | UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity | |
Biological Process | carbohydrate metabolic process | |
Biological Process | cell division | |
Biological Process | cell wall organization | |
Biological Process | lipid glycosylation | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | regulation of cell shape |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Spirochaetota > Spirochaetia > Spirochaetales > Exilispira
Accessions
- Primary accessionA0A847LN70
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 84-102 | Helical | ||||
Sequence: IADIFAFISGIFVSFFILL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 8-154 | Glycosyltransferase family 28 N-terminal | ||||
Sequence: IVVGGGTGGHIIPAVVVAKALKNKGYSVVWIGSKKSYELEEKLIRFSFPNIKIYHIPSGKLRRSGSTLRTLIDLRNIADIFAFISGIFVSFFILLKEKPLFVFSKGGFVSVPVAISCKMTKVPFFTHESDYTVGLANKINLKFSKKF | ||||||
Domain | 221-378 | Glycosyl transferase family 28 C-terminal | ||||
Sequence: ILILGGSLGSQRINNIIFKLAPILTQKYLIIHQTGKLNDLNLNFNSGKEEKINQGNSNKYFKFNPFGLKGYLQIEFIYNGIAELMKLSDLIISRAGANLVFEIVASKTPAIFIPLKTASRGEQENNARYFAKKGNYIVLDEEKLDDKILFNEIEKIFD |
Sequence similarities
Belongs to the glycosyltransferase 28 family. MurG subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length419
- Mass (Da)47,180
- Last updated2021-09-29 v1
- ChecksumBF136DBB2D4EAE35