A0A844I2X6 · A0A844I2X6_9CYAN

Function

function

Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site74Mg2+ (UniProtKB | ChEBI)
Binding site75Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site76Mg2+ (UniProtKB | ChEBI)
Binding site78Mg2+ (UniProtKB | ChEBI)
Binding site92Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site99Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmagnesium ion binding
Molecular Functionphosphoribosyl-AMP cyclohydrolase activity
Molecular Functionzinc ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosyl-AMP cyclohydrolase
  • EC number
  • Short names
    PRA-CH

Gene names

    • Name
      hisI
    • ORF names
      FJR37_05495

Organism names

  • Taxonomic identifier
  • Strain
    • UHCC 0183
  • Taxonomic lineage
    Bacteria > Cyanobacteriota > Cyanophyceae > Nostocales > Aphanizomenonaceae > Aphanizomenon

Accessions

  • Primary accession
    A0A844I2X6

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain27-101Phosphoribosyl-AMP cyclohydrolase

Sequence similarities

Belongs to the PRA-CH family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    111
  • Mass (Da)
    12,470
  • Last updated
    2021-09-29 v1
  • Checksum
    5FB506697B87620A
MIGNLKFNEQGLIPAIAQDYLDGTVLMMAWMNAESIQKTLATGEVYYWSRSRSQLWHKGATSTHIQKVKELFYDCDGDTILIKIEQVGDIACHTGARSCFFNSVGILSHKL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VILC01000011
EMBL· GenBank· DDBJ
MTJ29276.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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