A0A836AKE5 · A0A836AKE5_SHEEP

  • Protein
    Carbonyl reductase [NADPH] 1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • S-nitrosoglutathione + NADPH + H+ = S-(hydroxysulfenamide)glutathione + NADP+
  • menadione + NADPH + H+ = menadiol + NADP+
  • prostaglandin D2 + NADP+ = 15-oxoprostaglandin D2 + NADPH + H+
    This reaction proceeds in the forward direction.
    EC:1.1.1.196 (UniProtKB | ENZYME | Rhea)
  • prostaglandin E1 + NADP+ = 15-oxoprostaglandin E1 + NADPH + H+
    This reaction proceeds in the forward direction.
    EC:1.1.1.197 (UniProtKB | ENZYME | Rhea)
  • prostaglandin E2 + NADP+ = 15-oxoprostaglandin E2 + NADPH + H+
    This reaction proceeds in the forward direction.
  • prostaglandin F2alpha + NADP+ = 15-oxoprostaglandin F2alpha + NADPH + H+
    This reaction proceeds in the forward direction.
  • prostaglandin F2alpha + NADP+ = prostaglandin E2 + NADPH + H+
    This reaction proceeds in the backward direction.
    EC:1.1.1.189 (UniProtKB | ENZYME | Rhea)
  • a primary alcohol + NADP+ = an aldehyde + NADPH + H+
    EC:1.1.1.71 (UniProtKB | ENZYME | Rhea)
  • a secondary alcohol + NADP+ = a ketone + NADPH + H+
    EC:1.1.1.184 (UniProtKB | ENZYME | Rhea)
  • corticosterone + NADPH + H+ = 20beta-dihydrocorticosterone + NADP+
    This reaction proceeds in the forward direction.
  • cortisol + NADPH + H+ = 20beta-dihydrocortisol + NADP+
    This reaction proceeds in the forward direction.
  • daunorubicin + NADPH + H+ = 13-dihydrodaunorubicin + NADP+
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncarbonyl reductase (NADPH) activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carbonyl reductase [NADPH] 1
  • EC number
  • Alternative names
    • 15-hydroxyprostaglandin dehydrogenase [NADP(+)]
    • 20-beta-hydroxysteroid dehydrogenase
    • Alcohol dehydrogenase [NAD(P)+] CBR1
    • Prostaglandin 9-ketoreductase
    • Prostaglandin-E(2) 9-reductase

Gene names

    • ORF names
      JEQ12_001934

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Ovis

Accessions

  • Primary accession
    A0A836AKE5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    419
  • Mass (Da)
    46,335
  • Last updated
    2021-09-29 v1
  • Checksum
    EF1A0D25107A091F
MSSSTRVALVTGASKGVGFAIVRELCRQFQGDVVLTAPDEAQGRAAVQQLQAEGLSPRFHQLDIDDRQSIRAVRDFLSKEYGGLDVLVNNAGVAFKTADTTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSSVSVSSLKKCSPELQQKFRSETITEEELVGLMNKFVEDTKNGVHRKEGWPDTAYGVTKIGVTVLSRIHARKLSEQRGGDKILLNACCPGWLDITDLQSIRTLCDFLHKEYRGLNVLVNNTAIAFKSRVVNMSSGWGFKALESCSPELQQKLRSETITEEELVGLMNKFVEDTKNGVHTKEGWPDNNTYGVAKIGITALSRIQARKLSEQRGGDKILLNACCPGWVRTNMGGSKAPKSLEEGIETPVYLAFLPSDVEGPHGQFVHEKKVAKWQFMPEFYP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAEMGP010000001
EMBL· GenBank· DDBJ
KAG5216358.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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