A0A834K3W4 · A0A834K3W4_VESGE
- ProteinUbiquinone biosynthesis O-methyltransferase, mitochondrial
- Genecoq3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids906 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
Catalytic activity
- 3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H+ + S-adenosyl-L-homocysteine
3,4-dihydroxy-5-all-trans-polyprenylbenzoate RHEA-COMP:10930 + CHEBI:59789 = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate RHEA-COMP:10931 + CHEBI:15378 + CHEBI:57856
Pathway
Cofactor biosynthesis; ubiquinone biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 696 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 727 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 748 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 795 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: S |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | catalytic step 2 spliceosome | |
Cellular Component | extrinsic component of mitochondrial inner membrane | |
Cellular Component | nuclear speck | |
Molecular Function | 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity | |
Molecular Function | 3-demethylubiquinol-n 3-O-methyltransferase activity | |
Molecular Function | RNA binding | |
Biological Process | methylation | |
Biological Process | mRNA splicing, via spliceosome |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUbiquinone biosynthesis O-methyltransferase, mitochondrial
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Hymenoptera > Apocrita > Aculeata > Vespoidea > Vespidae > Vespinae > Vespula
Accessions
- Primary accessionA0A834K3W4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Subunit
Component of a multi-subunit COQ enzyme complex.
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 30-117 | Basic and acidic residues | ||||
Sequence: MERHSERRSERYSERYSDRHSERRSEKRSERRSEKHSERYSDRRPDKHSDKHSDKHSDKHSDKHSDKHSEKRSEKHSEKRHTTETMTN | ||||||
Region | 30-121 | Disordered | ||||
Sequence: MERHSERRSERYSERYSDRHSERRSEKRSERRSEKHSERYSDRRPDKHSDKHSDKHSDKHSDKHSDKHSEKRSEKHSEKRHTTETMTNNRKR | ||||||
Region | 404-437 | Disordered | ||||
Sequence: KEILGSDDSDSEAGEDDEESSDEDSNAEIAEEKE | ||||||
Compositional bias | 412-432 | Acidic residues | ||||
Sequence: SDSEAGEDDEESSDEDSNAEI | ||||||
Domain | 450-566 | MI | ||||
Sequence: ALRRTIYLTIHSSLDFEECAHKLMKMQLKPGQEIELCHMFLDCCAEMRTYEKFFGLLAGRFCAINKIYVTPFEQIFQDSYHTIHRLDTNKLRNVSKFFAHLLFTDSISWEVLSCIKL |
Sequence similarities
Belongs to the CWC22 family.
Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length906
- Mass (Da)103,923
- Last updated2021-09-29 v1
- ChecksumDFDB897420DDA98C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 30-117 | Basic and acidic residues | ||||
Sequence: MERHSERRSERYSERYSDRHSERRSEKRSERRSEKHSERYSDRRPDKHSDKHSDKHSDKHSDKHSDKHSEKRSEKHSEKRHTTETMTN | ||||||
Compositional bias | 412-432 | Acidic residues | ||||
Sequence: SDSEAGEDDEESSDEDSNAEI |
Keywords
- Technical term