A0A833ZK58 · A0A833ZK58_9CHIR
- ProteinBifunctional arginine demethylase and lysyl-hydroxylase JMJD6
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids361 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 2-oxoglutarate + 2 O2 = L-arginyl-[protein] + 2 formaldehyde + 2 succinate + 2 CO2
- L-lysyl-[protein] + 2-oxoglutarate + O2 = (5S)-5-hydroxy-L-lysyl-[protein] + succinate + CO2
- N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2-oxoglutarate + O2 = N(omega)-methyl-L-arginyl-[protein] + formaldehyde + succinate + CO2
- a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + 2-oxoglutarate + O2 = a 5'-end triphospho-guanosine-ribonucleotide-snRNA + formaldehyde + succinate + CO2 + H+
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | histone H4R3 demethylase activity | |
Molecular Function | methyltransferase activity | |
Molecular Function | P-TEFb complex binding | |
Biological Process | methylation | |
Biological Process | phagocytosis |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameBifunctional arginine demethylase and lysyl-hydroxylase JMJD6
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Phyllostomidae > Phyllostominae > Phyllostomus
Accessions
- Primary accessionA0A833ZK58
Proteomes
Subcellular Location
Interaction
Subunit
Homooligomerizes; requires lysyl-hydroxylase activity. Interacts with LUC7L2, LUC7L3 and U2AF2/U2AF65. Interacts with CDK9 and CCNT1; the interaction is direct with CDK9 and associates the P-TEFb complex when active. Interacts (via JmjC and N-terminal domains) with BRD4 (via NET domain); the interaction is stronger in presence of ssRNA and recruits JMJD6 on distal enhancers.
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 141-305 | JmjC | ||||
Sequence: PKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTREEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKTVRGR | ||||||
Region | 324-361 | Disordered | ||||
Sequence: HATPSHPVPLCPNPDLEGPALGDPEAGAARAGGPGGLR |
Sequence similarities
Belongs to the JMJD6 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length361
- Mass (Da)41,681
- Last updated2021-09-29 v1
- ChecksumD72AFDB15C5E5549