A0A833ZK58 · A0A833ZK58_9CHIR

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionhistone H4R3 demethylase activity
Molecular Functionmethyltransferase activity
Molecular FunctionP-TEFb complex binding
Biological Processmethylation
Biological Processphagocytosis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
  • Alternative names
    • Histone arginine demethylase JMJD6
    • JmjC domain-containing protein 6
    • Jumonji domain-containing protein 6
    • Lysyl-hydroxylase JMJD6
    • Peptide-lysine 5-dioxygenase JMJD6
    • Phosphatidylserine receptor

Gene names

    • ORF names
      HJG60_007005

Organism names

  • Taxonomic identifier
  • Strain
    • Bat1K_MPI-CBG_1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Phyllostomidae > Phyllostominae > Phyllostomus

Accessions

  • Primary accession
    A0A833ZK58

Proteomes

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Homooligomerizes; requires lysyl-hydroxylase activity. Interacts with LUC7L2, LUC7L3 and U2AF2/U2AF65. Interacts with CDK9 and CCNT1; the interaction is direct with CDK9 and associates the P-TEFb complex when active. Interacts (via JmjC and N-terminal domains) with BRD4 (via NET domain); the interaction is stronger in presence of ssRNA and recruits JMJD6 on distal enhancers.

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain141-305JmjC
Region324-361Disordered

Sequence similarities

Belongs to the JMJD6 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    361
  • Mass (Da)
    41,681
  • Last updated
    2021-09-29 v1
  • Checksum
    D72AFDB15C5E5549
MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLNPAAVVDNVERADALQLSVEEFVERYERPYKPVVLLSAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTREEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKTVRGRPKLSRKWYRTDTARAAAVHATPSHPVPLCPNPDLEGPALGDPEAGAARAGGPGGLR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABVXQ010000008
EMBL· GenBank· DDBJ
KAF6094403.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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