A0A833VSY1 · A0A833VSY1_9CERV

Function

function

Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
Plays a central role in autophagy.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentautophagosome
Cellular Componentendoplasmic reticulum membrane
Cellular Componentendosome membrane
Cellular ComponentGolgi apparatus
Cellular Componentmitochondrial membrane
Cellular Componentnucleus
Cellular Componentphagophore assembly site
Cellular Componentphosphatidylinositol 3-kinase complex, class III, type I
Cellular Componentphosphatidylinositol 3-kinase complex, class III, type II
Biological Processapoptotic process
Biological Processautophagosome assembly
Biological Processcell division
Biological Processcellular response to nitrogen starvation
Biological Processdefense response to virus
Biological Processearly endosome to late endosome transport
Biological Processlate endosome to vacuole transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Beclin-1

Gene names

    • ORF names
      G4228_020277

Organism names

  • Taxonomic identifier
  • Strain
    • CEY-2017
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Cervidae > Cervinae > Cervus

Accessions

  • Primary accession
    A0A833VSY1

Proteomes

Subcellular Location

Cytoplasm
Golgi apparatus, trans-Golgi network membrane
; Peripheral membrane protein
Endosome membrane
; Peripheral membrane protein
Endoplasmic reticulum membrane
; Peripheral membrane protein
Mitochondrion membrane
; Peripheral membrane protein
Nucleus

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, coiled coil.

Type
IDPosition(s)Description
Domain103-127Beclin-1 BH3
Domain133-259Atg6/beclin coiled-coil
Coiled coil143-265
Domain262-443Atg6 BARA

Sequence similarities

Belongs to the beclin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    448
  • Mass (Da)
    51,561
  • Last updated
    2021-09-29 v1
  • MD5 Checksum
    6E23A1F06D6914A61675A23C94FD4B2F
MEGSKTSSSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLATAQLKPGETQEEEASSGEEPFIETCQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLGLELNELALEEERLIQELEDVEKNRKMVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQMQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLWFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFNSEEQWTKPLKFMLTNLKWGLAWVSSQFYNK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WMHW01002157
EMBL· GenBank· DDBJ
KAF4008525.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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