A0A829XAJ9 · A0A829XAJ9_GLUOY
- ProteinGlycerol-3-phosphate dehydrogenase [NAD(P)+]
- GenegpsA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids324 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.
Catalytic activity
- sn-glycerol 3-phosphate + NAD+ = dihydroxyacetone phosphate + NADH + H+
Pathway
Membrane lipid metabolism; glycerophospholipid metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 11-16 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 15 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 35 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 101 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 101 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 101 | substrate | |||
Binding site | 129 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 133 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 133 | NADPH (UniProtKB | ChEBI) | |||
Active site | 184 | Proton acceptor | |||
Binding site | 184 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 237 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 247 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 248 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 248 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 248 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 248-249 | substrate | |||
Binding site | 249 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 272 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 274 | NADPH (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | glycerol-3-phosphate dehydrogenase [NAD(P)+] activity | |
Molecular Function | NAD binding | |
Biological Process | carbohydrate metabolic process | |
Biological Process | glycerol-3-phosphate biosynthetic process | |
Biological Process | glycerol-3-phosphate catabolic process | |
Biological Process | glycerophospholipid metabolic process | |
Biological Process | phospholipid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlycerol-3-phosphate dehydrogenase [NAD(P)+]
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rhodospirillales > Acetobacteraceae > Gluconobacter
Accessions
- Primary accessionA0A829XAJ9
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-20 | ||||
Chain | PRO_5032539508 | 21-324 | Glycerol-3-phosphate dehydrogenase [NAD(P)+] | ||
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 7-153 | Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal | |||
Domain | 173-312 | Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal | |||
Sequence similarities
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length324
- Mass (Da)33,248
- Last updated2021-09-29 v1
- MD5 ChecksumEFF0CF2E624FBA240DCEC818CE1199E3
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BARJ01000010 EMBL· GenBank· DDBJ | GEM17466.1 EMBL· GenBank· DDBJ | Genomic DNA |