A0A821RHE9 · A0A821RHE9_9BILA

  • Protein
    Dihydropyrimidine dehydrogenase [NADP(+)]
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

FMN (UniProtKB | Rhea| CHEBI:58210 )

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.

Pathway

Amino-acid biosynthesis; beta-alanine biosynthesis.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functiondihydropyrimidine dehydrogenase (NADP+) activity
Molecular Functionmetal ion binding
Molecular FunctionNADP binding
Molecular Functionuracil binding
Biological Processbeta-alanine biosynthetic process
Biological Processthymine catabolic process
Biological Processuracil catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydropyrimidine dehydrogenase [NADP(+)]
  • EC number
  • Short names
    DHPDHase
    ; DPD
  • Alternative names
    • Dihydrothymine dehydrogenase
    • Dihydrouracil dehydrogenase

Gene names

    • ORF names
      QYT958_LOCUS26596

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Gnathifera > Rotifera > Eurotatoria > Bdelloidea > Rotaria

Accessions

  • Primary accession
    A0A821RHE9

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain67-175Dihydroprymidine dehydrogenase
Domain197-505FAD/NAD(P)-binding
Domain543-736Dihydroorotate dehydrogenase catalytic

Sequence similarities

Belongs to the dihydropyrimidine dehydrogenase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    740
  • Mass (Da)
    80,911
  • Last updated
    2021-09-29 v1
  • Checksum
    9EE71FF20DD627F3
MPSENTTEQQLLSKDPPDIESLLLLNPRTKPFANSRPSVQTLQEKKHWKRNDEHSCATGCTKDLSRNFLDVKHTTLSERGALREAARCLKCADAPCQKSCPTSIDIKSFITSISNKNYYGAAKAILSDNPLGLTCGMVCPTSDLCVGGCNLHASEEGAINIGGLQQFAVDIFKSMHIPAIRDPSSEGVPLNEKYSSKIALIGCGPASISCATFLGRLGYSDLTIFEKQDFLGGLSSSEIPQYRLPFDTVNFEIELMKDLGVKIIPNKPLTTENDGLTIKNLLNEHGFKAVFLGIGLPNPNIDPIFKDLTKAEGFYTSKNFLPLIAKSSKAGMCACKSALPVMSGNVIVLGAGDTAMDCATSAIRCGATKVFVCFRKGFNQMRAVPEEVDVAMEERCEFLPFCSPKQVFVKNGKITSMEFVKTEQTESGDWIEDEDQIIRLKCNYVISAFGSTLNEHPVVQALAPIQLDKYNYPVVDLTTMTTSEKGVFCGGDIAKVASTTVECVNDGKTAAWHIHRYIQGVETIPLEPQLPKFYTPIDKVDVSVEICGIKFPNPFGLASAPPVTSGPMIRRSFESGWGFVVTKTYCLDKDIITNVSPRIVRGTTSGFNYGPGQGSFLNIELISEKNTEYWLRCITELKRDFPDRIVIASIMCGYNEADWTELAKVTESSGADALELNLSCPHGMGEKGMGLACGQRADLVLNICKWVRAAVKIPFFAKMTPNITNIIDIARAAKEGKKMN

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAJOBR010006404
EMBL· GenBank· DDBJ
CAF4843208.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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