A0A820GBY7 · A0A820GBY7_9BILA

  • Protein
    7-dehydrocholesterol reductase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta24-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionguanyl-nucleotide exchange factor activity
Molecular Functionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
Biological Processbrassinosteroid biosynthetic process
Biological Processcholesterol biosynthetic process
Biological Processsmall GTPase-mediated signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    7-dehydrocholesterol reductase
  • EC number
  • Alternative names
    • Sterol Delta(7)-reductase

Gene names

    • ORF names
      HFQ381_LOCUS11800

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Gnathifera > Rotifera > Eurotatoria > Bdelloidea > Rotaria

Accessions

  • Primary accession
    A0A820GBY7

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane883-903Helical
Transmembrane942-961Helical
Transmembrane981-1001Helical
Transmembrane1013-1033Helical
Transmembrane1103-1120Helical
Transmembrane1135-1153Helical
Transmembrane1256-1275Helical

Keywords

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain160-286N-terminal Ras-GEF
Domain333-611Ras-GEF
Compositional bias610-626Basic and acidic residues
Region610-635Disordered

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,308
  • Mass (Da)
    150,513
  • Last updated
    2021-09-29 v1
  • Checksum
    0A5EF4F1CE1219BC
MLFPKIGSEFEFDVPETTSNPVLRPSLSAPFIGTHQQAWPSNSARSLGRESYQSSVEDLSLINKFVSSFRISFHQSNILKQLKQRCSNNNNNNQNTEQPQLICEERQENAIFKIFLKRLRKKPPTSIGSSSDFNRLLDDHDEQNELNKNDQSTLLYSTIKIYQLKAGTLEKIVECLTNKYGDLDTTHMLILFATYRIYTNTRILIDTILSRYQAVLPASLDMTEDVRQKTLKSLSMALICLLTAYKEDFNEPPYYTILNHLLQQITDRDVHNQCQSLLNRFLTEENTSKSTPTMFTLTHDIDNNNNSKNLFTDNIYNQKGLEHSIPKNLLEMSHVMIAEQLTIVDAELLKCVLPHEYLTMQGNSNKRRGLNPMNVSSTVDKTIEQFNAVVNRVIATILTELNELTRVRLIEKWIDVAYECRQLKNFSSLTAILTGLLSGSVYRLTKTWSQINIQHRTVLNGLKNIFGSCADRKQARDILDKEGTAKYVDATAAMNATISKKLRSKKSRNQKQMMIGTVPYLGLYSSDLTYIDSAHNNYINSNENDKSSQKLINFEKNRKQFEILAKIKLFQSAANAYTTLQPLPDFKHWFDNIQIFTVAESWDLSYRIEPKPMDNTDKKQKLQDDPSPNSRARPVKAFPSEVSLDVFMTRNNPARESKPVFGGSLRSSPSLNSYDKISLTSNHSFPHRQQSICSLTNKKTHSRSSSASSFLTKDSLSQGYISAQASPVNSPANCTFNPVENDTLIAKVRLIGRDNLLYKKVRIGNNERASNVLKTILDKFCIDPTTHEDYCIEQQLPTRRLLLLDHYNVFYALVRQSDDEQVELIVRKKFLSSVDMSKHGEEKHKRKFQSGKIGDLTVNSNDSTHQLSIHIRHGHNKFWSESILPLTLCVACPFLVRSIVFICDHSHGSIMEFFSHILFDQTMTLKQVLVNFFYFQWHWPSALIIISFLIYAVIMTMLIPGDEYSGPITDTGHVPVYHNNGFTYYVISLILFALLTALLKFNNISPTYIYDHWEEFLSTVNTFAFLLCFLVILKGKYMPSTNDHRSSSNWLTDFYRGVELYPRIFNIDIKLITNCRYGMLSWALLSIIFCMKTFELHGYTDSALVSCLLTLVYLTKFFWWESGYMKTMDIIVDRAGFYLCWGCLVWVSGIYTLPSYFLVTHPNKLGLSSTIAVLALGFLSIYINYDCDRQKIDVRTSNGQCDVWGKQATVIRAKYLLLNGKESESILLASGYWALSRHFHYVPELALAFLWSYPCGFHYILPYFYFIFLCVLLIHRAHRDDQKCRLKYGAVWDKYCQLVRWKIFPGLY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias610-626Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAJOBO010000691
EMBL· GenBank· DDBJ
CAF4273306.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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