A0A820GBY7 · A0A820GBY7_9BILA
- Protein7-dehydrocholesterol reductase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1308 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta24-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation.
Catalytic activity
- 7-dehydrodesmosterol + NADPH + H+ = desmosterol + NADP+This reaction proceeds in the forward direction.
Pathway
Steroid biosynthesis; cholesterol biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | guanyl-nucleotide exchange factor activity | |
Molecular Function | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | |
Biological Process | brassinosteroid biosynthetic process | |
Biological Process | cholesterol biosynthetic process | |
Biological Process | small GTPase-mediated signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name7-dehydrocholesterol reductase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Gnathifera > Rotifera > Eurotatoria > Bdelloidea > Rotaria
Accessions
- Primary accessionA0A820GBY7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 883-903 | Helical | ||||
Sequence: ILPLTLCVACPFLVRSIVFIC | ||||||
Transmembrane | 942-961 | Helical | ||||
Sequence: ALIIISFLIYAVIMTMLIPG | ||||||
Transmembrane | 981-1001 | Helical | ||||
Sequence: GFTYYVISLILFALLTALLKF | ||||||
Transmembrane | 1013-1033 | Helical | ||||
Sequence: WEEFLSTVNTFAFLLCFLVIL | ||||||
Transmembrane | 1103-1120 | Helical | ||||
Sequence: ALVSCLLTLVYLTKFFWW | ||||||
Transmembrane | 1135-1153 | Helical | ||||
Sequence: AGFYLCWGCLVWVSGIYTL | ||||||
Transmembrane | 1256-1275 | Helical | ||||
Sequence: GFHYILPYFYFIFLCVLLIH |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 160-286 | N-terminal Ras-GEF | ||||
Sequence: KIYQLKAGTLEKIVECLTNKYGDLDTTHMLILFATYRIYTNTRILIDTILSRYQAVLPASLDMTEDVRQKTLKSLSMALICLLTAYKEDFNEPPYYTILNHLLQQITDRDVHNQCQSLLNRFLTEEN | ||||||
Domain | 333-611 | Ras-GEF | ||||
Sequence: SHVMIAEQLTIVDAELLKCVLPHEYLTMQGNSNKRRGLNPMNVSSTVDKTIEQFNAVVNRVIATILTELNELTRVRLIEKWIDVAYECRQLKNFSSLTAILTGLLSGSVYRLTKTWSQINIQHRTVLNGLKNIFGSCADRKQARDILDKEGTAKYVDATAAMNATISKKLRSKKSRNQKQMMIGTVPYLGLYSSDLTYIDSAHNNYINSNENDKSSQKLINFEKNRKQFEILAKIKLFQSAANAYTTLQPLPDFKHWFDNIQIFTVAESWDLSYRIEPK | ||||||
Compositional bias | 610-626 | Basic and acidic residues | ||||
Sequence: PKPMDNTDKKQKLQDDP | ||||||
Region | 610-635 | Disordered | ||||
Sequence: PKPMDNTDKKQKLQDDPSPNSRARPV |
Sequence similarities
Belongs to the ERG4/ERG24 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,308
- Mass (Da)150,513
- Last updated2021-09-29 v1
- Checksum0A5EF4F1CE1219BC
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 610-626 | Basic and acidic residues | ||||
Sequence: PKPMDNTDKKQKLQDDP |