A0A815YZ30 · A0A815YZ30_9BILA
- Protein7-dehydrocholesterol reductase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1302 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta24-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation.
Catalytic activity
- 7-dehydrodesmosterol + NADPH + H+ = desmosterol + NADP+This reaction proceeds in the forward direction.
Pathway
Steroid biosynthesis; cholesterol biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | guanyl-nucleotide exchange factor activity | |
Molecular Function | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | |
Biological Process | brassinosteroid biosynthetic process | |
Biological Process | cholesterol biosynthetic process | |
Biological Process | small GTPase-mediated signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name7-dehydrocholesterol reductase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Gnathifera > Rotifera > Eurotatoria > Bdelloidea > Rotaria
Accessions
- Primary accessionA0A815YZ30
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 931-955 | Helical | ||||
Sequence: WHWPSALILLSVFAYSIIMAVLLPG | ||||||
Transmembrane | 976-995 | Helical | ||||
Sequence: FTYYIVSLIIFALLTLLLKL | ||||||
Transmembrane | 1010-1027 | Helical | ||||
Sequence: FLSTVNTFAFLLCFLVMI | ||||||
Transmembrane | 1073-1091 | Helical | ||||
Sequence: MLAWALLSVIFCMKTFELY | ||||||
Transmembrane | 1097-1113 | Helical | ||||
Sequence: ALVTCILTLVYLTKFFW | ||||||
Transmembrane | 1125-1147 | Helical | ||||
Sequence: IVDRAGFYLCWGCLVWVSGIYTL | ||||||
Transmembrane | 1159-1179 | Helical | ||||
Sequence: LGPVLTAIILLLGFLAIYVNY |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, coiled coil, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 113-238 | N-terminal Ras-GEF | ||||
Sequence: KVYQLKAGTLEKVVEYLTDETGELDTTHMHILFSTYRTFTNTRTLIETLIKRYRAVLPASLDMTEDMRQKSVKSLRTAMTYFLNSYKEDFCEPPYYSTLNYLIKHIPERDLLKQCQILLDELKKNE | ||||||
Coiled coil | 220-251 | |||||
Sequence: ERDLLKQCQILLDELKKNEENIQSNIVDNNNN | ||||||
Domain | 277-559 | Ras-GEF | ||||
Sequence: SSTMIAEQLTIVDADLLKRVLPHECLTLSTGSCSRRTPGNNSDRTLSTVDKTIQYFNAVVARVIATILKEQDEHIRAHVIEKWIDVAHQCRKIKNFSSLTAILNGLLSGCIYRLNKAWSYVTDDYKLILDELKNVFGSCADRKQTRTILEKECLTKYTDVSTPINATLGRKYRHKMTRDQQRSTTIGAVPYLGFYLSDLTYIDSAYQNTIPIENGDPSSSKKLINFEKHRKIFEVLAQIKLFQSAANAYSTLQSISRFKAWFDNVRIYNDTESWELSYQIEPK | ||||||
Region | 561-615 | Disordered | ||||
Sequence: VTDCSQPQEQSSPSYRSQPRIKSIMQRVPSVVSLESQTTSNNENNGSMITSATSL | ||||||
Region | 637-666 | Disordered | ||||
Sequence: QQHCQNQPLRPDKNSNINHSRSSSTSSFLT | ||||||
Domain | 698-787 | Ras-associating | ||||
Sequence: DTIIAKVQFTGKNDLLYKKVRIRNDERTTSVLKTILDKFGLDPSTYERYCIEQRLPDRKILILDHCNVFYALARSSDDEQVDLIVREKTQ | ||||||
Region | 791-816 | Disordered | ||||
Sequence: QTKSNNLMDSSGHNRTPSGYSTTSSI |
Sequence similarities
Belongs to the ERG4/ERG24 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,302
- Mass (Da)149,729
- Last updated2021-09-29 v1
- Checksum8448F0CD41C87963