A0A813X5R8 · A0A813X5R8_9BILA

  • Protein
    7-dehydrocholesterol reductase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta24-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionguanyl-nucleotide exchange factor activity
Molecular Functionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
Biological Processbrassinosteroid biosynthetic process
Biological Processcholesterol biosynthetic process
Biological Processsmall GTPase-mediated signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    7-dehydrocholesterol reductase
  • EC number
  • Alternative names
    • Sterol Delta(7)-reductase

Gene names

    • ORF names
      JXQ802_LOCUS7386

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Gnathifera > Rotifera > Eurotatoria > Bdelloidea > Rotaria

Accessions

  • Primary accession
    A0A813X5R8

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane1002-1026Helical
Transmembrane1047-1066Helical
Transmembrane1081-1098Helical
Transmembrane1142-1162Helical
Transmembrane1168-1189Helical
Transmembrane1201-1224Helical
Transmembrane1230-1250Helical
Transmembrane1313-1338Helical

Keywords

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain168-293N-terminal Ras-GEF
Domain329-627Ras-GEF
Compositional bias636-707Polar residues
Region636-757Disordered
Compositional bias718-757Polar residues
Domain761-850Ras-associating
Region849-880Disordered
Compositional bias855-880Polar residues

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,373
  • Mass (Da)
    158,210
  • Last updated
    2021-09-29 v1
  • Checksum
    596658FEEF6AE14F
MSLYRRPIRRIVISAKTGLLINKTTLKSFSQQNIYAQLEETHLVSQCKRSFTFRLMYVDSSESDIELHPFDLTSLLVILHPANSKLIDRSRQINSHQLNTEQPQFIGEERQDDAIFKIYLKRVRHKSSTLVDSSSTINTLVDDTNEQHETTGDNHNNDRGTLLYSTIKVYQLKACTLEKIVEHLTNDTGELDTTNMHILFSTYRTFTNTRTLIDTLITRYRAVLPASLDMTEDVRQKTLKSLHVAITCFLNSCKEDFCHPPRYSILNHFIKHIPDRDLQKQGQTLLEEFKTDEETIKLNNNNNNNLKTNFLYNEKGFDYIKPWNILEMSSTMIAEQLTIVDADLLKRVLPYECLTIPTGGCSRRALNNNSNRILSTIDKTIEYFNAVVARVVATILKEQDEQNRAHVIEKWIDVAHQCRKLKNFSSLTAILNGLLSGCIYRLNTAWSHVKQDYQSILEELKNVFGSCADRKQARAILDKQLDEVRLMQPEYTECAAKYTHVTTAINATLGRKYRHKMARDQQKLTMLGTVPYLGLYLSDLTYIDSAYPNTIIIEDDNSPSCTSSKKLINFEKHRKQFEVLAQIKLFQSAANAYTTLHPLPRFKAWFDNVRIYNDTESWELSYQIEPKEIIDNSQSQEQLLQNHGSPSLKSTSERFPSEVSLEPRVISNNNENNGSMVISSTSLKSSSSTSLDKISTISNNSLRQQQQLRKDKNSHIYHSRSSSASSFLTSSNGSSSQGHLSATASPKINTGNSTSNSSENEAIIAKVHFAGNNDLLYKKVRINNNERTTSVLKTILDKFGLDPSTYDQYCIEQQLPDRKILILDHCNVFYALARSSDDEQVELIVREKTRQERQQKCNNPLSGGAGHNRTPSGFSTSSIHSPTITNSEYPITSIQYLKTIMTDYNDEKLRKKSLSKKNDSELLLKNDRTHQLSIHTRQGHNKVLSESILPLILCLACPFFVRSIVFICDHCHGSIIEFLQRLLFDQTMTLKDVLEDFFYFQWHWPSAVIILSVFTYAIIMTMLLPGDEYSGPITDTGHVPIYRNNGFSYYIVSLVIFALLTVILKLNNLSPTYIYDHWKEFLSTVNTFAFLLCFLVMIKGKYMPSTDDHRSSSNWLTDFYRGVELYPRIFNIDIKLITNCRYGMLTWALLSVIFCMKTFELYGYTDSALVTCILTLMYLTKFFWWESGYMKTIDIIVDRGGFYLCWGCLVWVSGIYTLPSYFLVKHPNQLGFVLTSIALLLGILSIYVNYDCDRQKIDVRSKHGECLIWGKPAEIIRAKYRLLNGKECESILLASGYWSLSRHFHYIPELALAFLWTCPCGFKYILPYFYFIILFVLLMHRAHRDDQKCTLKYGQTWVKYCHLVPWKVWPRIY

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A813XHP3A0A813XHP3_9BILAJXQ802_LOCUS73861318

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias636-707Polar residues
Compositional bias718-757Polar residues
Compositional bias855-880Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAJNOL010000123
EMBL· GenBank· DDBJ
CAF0865022.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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