A0A813X5R8 · A0A813X5R8_9BILA
- Protein7-dehydrocholesterol reductase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1373 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta24-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation.
Catalytic activity
- 7-dehydrodesmosterol + NADPH + H+ = desmosterol + NADP+This reaction proceeds in the forward direction.
Pathway
Steroid biosynthesis; cholesterol biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | guanyl-nucleotide exchange factor activity | |
Molecular Function | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | |
Biological Process | brassinosteroid biosynthetic process | |
Biological Process | cholesterol biosynthetic process | |
Biological Process | small GTPase-mediated signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name7-dehydrocholesterol reductase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Gnathifera > Rotifera > Eurotatoria > Bdelloidea > Rotaria
Accessions
- Primary accessionA0A813X5R8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 1002-1026 | Helical | ||||
Sequence: WHWPSAVIILSVFTYAIIMTMLLPG | ||||||
Transmembrane | 1047-1066 | Helical | ||||
Sequence: FSYYIVSLVIFALLTVILKL | ||||||
Transmembrane | 1081-1098 | Helical | ||||
Sequence: FLSTVNTFAFLLCFLVMI | ||||||
Transmembrane | 1142-1162 | Helical | ||||
Sequence: YGMLTWALLSVIFCMKTFELY | ||||||
Transmembrane | 1168-1189 | Helical | ||||
Sequence: ALVTCILTLMYLTKFFWWESGY | ||||||
Transmembrane | 1201-1224 | Helical | ||||
Sequence: GFYLCWGCLVWVSGIYTLPSYFLV | ||||||
Transmembrane | 1230-1250 | Helical | ||||
Sequence: LGFVLTSIALLLGILSIYVNY | ||||||
Transmembrane | 1313-1338 | Helical | ||||
Sequence: AFLWTCPCGFKYILPYFYFIILFVLL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 168-293 | N-terminal Ras-GEF | ||||
Sequence: KVYQLKACTLEKIVEHLTNDTGELDTTNMHILFSTYRTFTNTRTLIDTLITRYRAVLPASLDMTEDVRQKTLKSLHVAITCFLNSCKEDFCHPPRYSILNHFIKHIPDRDLQKQGQTLLEEFKTDE | ||||||
Domain | 329-627 | Ras-GEF | ||||
Sequence: SSTMIAEQLTIVDADLLKRVLPYECLTIPTGGCSRRALNNNSNRILSTIDKTIEYFNAVVARVVATILKEQDEQNRAHVIEKWIDVAHQCRKLKNFSSLTAILNGLLSGCIYRLNTAWSHVKQDYQSILEELKNVFGSCADRKQARAILDKQLDEVRLMQPEYTECAAKYTHVTTAINATLGRKYRHKMARDQQKLTMLGTVPYLGLYLSDLTYIDSAYPNTIIIEDDNSPSCTSSKKLINFEKHRKQFEVLAQIKLFQSAANAYTTLHPLPRFKAWFDNVRIYNDTESWELSYQIEPK | ||||||
Compositional bias | 636-707 | Polar residues | ||||
Sequence: QEQLLQNHGSPSLKSTSERFPSEVSLEPRVISNNNENNGSMVISSTSLKSSSSTSLDKISTISNNSLRQQQQ | ||||||
Region | 636-757 | Disordered | ||||
Sequence: QEQLLQNHGSPSLKSTSERFPSEVSLEPRVISNNNENNGSMVISSTSLKSSSSTSLDKISTISNNSLRQQQQLRKDKNSHIYHSRSSSASSFLTSSNGSSSQGHLSATASPKINTGNSTSNS | ||||||
Compositional bias | 718-757 | Polar residues | ||||
Sequence: HSRSSSASSFLTSSNGSSSQGHLSATASPKINTGNSTSNS | ||||||
Domain | 761-850 | Ras-associating | ||||
Sequence: EAIIAKVHFAGNNDLLYKKVRINNNERTTSVLKTILDKFGLDPSTYDQYCIEQQLPDRKILILDHCNVFYALARSSDDEQVELIVREKTR | ||||||
Region | 849-880 | Disordered | ||||
Sequence: TRQERQQKCNNPLSGGAGHNRTPSGFSTSSIH | ||||||
Compositional bias | 855-880 | Polar residues | ||||
Sequence: QKCNNPLSGGAGHNRTPSGFSTSSIH |
Sequence similarities
Belongs to the ERG4/ERG24 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,373
- Mass (Da)158,210
- Last updated2021-09-29 v1
- Checksum596658FEEF6AE14F
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A813XHP3 | A0A813XHP3_9BILA | JXQ802_LOCUS7386 | 1318 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 636-707 | Polar residues | ||||
Sequence: QEQLLQNHGSPSLKSTSERFPSEVSLEPRVISNNNENNGSMVISSTSLKSSSSTSLDKISTISNNSLRQQQQ | ||||||
Compositional bias | 718-757 | Polar residues | ||||
Sequence: HSRSSSASSFLTSSNGSSSQGHLSATASPKINTGNSTSNS | ||||||
Compositional bias | 855-880 | Polar residues | ||||
Sequence: QKCNNPLSGGAGHNRTPSGFSTSSIH |
Keywords
- Technical term