A0A812V547 · A0A812V547_9DINO

  • Protein
    Oxidized purine nucleoside triphosphate hydrolase
  • Gene
    Nudt1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • 2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • 2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H+
    This reaction proceeds in the forward direction.
    EC:3.6.1.56 (UniProtKB | ENZYME | Rhea)
  • 8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • 8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • N6-methyl-ATP + H2O = N6-methyl-AMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • N6-methyl-dATP + H2O = N6-methyl-dAMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • O6-methyl-dGTP + H2O = O6-methyl-dGMP + diphosphate + H+
    This reaction proceeds in the forward direction.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
Molecular Functionmetal ion binding
Biological ProcessDNA protection

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Oxidized purine nucleoside triphosphate hydrolase
  • EC number
  • Alternative names
    • 2-hydroxy-dATP diphosphatase
    • 7,8-dihydro-8-oxoguanine triphosphatase
    • 8-oxo-dGTPase
    • Methylated purine nucleoside triphosphate hydrolase
    • Nucleoside diphosphate-linked moiety X motif 1

Gene names

    • Name
      Nudt1
    • ORF names
      SNAT2548_LOCUS34076

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Dinophyceae > Suessiales > Symbiodiniaceae > Symbiodinium

Accessions

  • Primary accession
    A0A812V547

Proteomes

Subcellular Location

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-143Nudix hydrolase

Sequence similarities

Belongs to the Nudix hydrolase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    573
  • Mass (Da)
    64,288
  • Last updated
    2021-09-29 v1
  • Checksum
    132E8C00C36C01E8
MTSPQFESREKSVLTLIYPRVPSQRLVLLGLKKRGFGQGKFNGFGGKLEAGESLEEGALRELREECGLRADLTSLTWRGCLTYIYDTKPKAMEVNIFDLEAWGGEPEETEEMKPAWYSHEEIPLEKMWADDAYWLLQYLNQQMATPFVGRFRFKGHEGPDSWKVLEHFVRPLLPASVPRMGPSAQIEPGAALLVSTVSFIGAPSARPLESFIRYHLLKGFARVMIFVDDPADSATLDAVRRFPASRVLYRVRGEELWREQRQHCSSFDKLEGFVDEVSARQLLDFELASKLAPSLGCGWILCLDSDELLYTREESVVPHLQSLESQGIYQMSYLNHEAVPEQPETLDYFATVSLFKLHQFAVPLTAKARSGLRFWMNRSKHGQYFLFYDNGKSACRTGLAATPASQHLWQLPSGYKSCTALADPRRMDVEGFRECKDPCVLHFPVCGSAWLTAKYKTLGEFPDKWLGNMPLNESFHKDAREAQLRGGDTLKTMFMEQVLLDSREATAQIACGTCTRLTEHLTTLDAVSTGTVAPDATADGAADSYAVANGDRAVGVERGWILSKAMGYLSPEL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAJNDS010002791
EMBL· GenBank· DDBJ
CAE7598897.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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