A0A812TUM1 · A0A812TUM1_9DINO
- Proteinbranched-chain-amino-acid transaminase
- GeneilvE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2731 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Acts on leucine, isoleucine and valine.
Catalytic activity
- 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate
Cofactor
Pathway
Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.
Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.
Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 1356 | Nucleophile | ||||
Sequence: C | ||||||
Active site | 1445 | |||||
Sequence: H | ||||||
Active site | 1447 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | membrane | |
Molecular Function | branched-chain-amino-acid transaminase activity | |
Molecular Function | metalloendopeptidase activity | |
Biological Process | base-excision repair | |
Biological Process | CAAX-box protein processing | |
Biological Process | glutamine metabolic process | |
Biological Process | isoleucine biosynthetic process | |
Biological Process | L-leucine biosynthetic process | |
Biological Process | valine biosynthetic process |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namebranched-chain-amino-acid transaminase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Sar > Alveolata > Dinophyceae > Suessiales > Symbiodiniaceae > Symbiodinium
Accessions
- Primary accessionA0A812TUM1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 335-359 | Helical | ||||
Sequence: VLLVIVAVPIALMIEAIMSIVFGGY | ||||||
Transmembrane | 371-393 | Helical | ||||
Sequence: VYGSLWYVTSWIPTFAILAYLMI | ||||||
Transmembrane | 414-442 | Helical | ||||
Sequence: SVGLLCALVWFASYFFVAVVFSVSGLWMV | ||||||
Transmembrane | 462-483 | Helical | ||||
Sequence: GWVWAIVAAGTLVSAFAEEWVF | ||||||
Transmembrane | 495-514 | Helical | ||||
Sequence: GMGSARAVLCSSALFATYHI | ||||||
Transmembrane | 520-538 | Helical | ||||
Sequence: AFVDIFVSGCLFAMVFLCL | ||||||
Transmembrane | 879-902 | Helical | ||||
Sequence: FGVFFGLLVLMVVLVVLGMIVFLI | ||||||
Transmembrane | 922-942 | Helical | ||||
Sequence: LAVRVGFVIALCVMIVGVYRL | ||||||
Transmembrane | 954-976 | Helical | ||||
Sequence: GNWRMWMLAGPFCLIGLIVIGAI | ||||||
Transmembrane | 988-1009 | Helical | ||||
Sequence: RWAMSLSLVLTMVCAWVSYIAM | ||||||
Transmembrane | 1041-1068 | Helical | ||||
Sequence: VVVCMILAIPAFVSFSTVAGLVQLAVLI |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-29 | Disordered | ||||
Sequence: MDAGRHTHQKKELLMSSAQASGATTVENA | ||||||
Compositional bias | 13-29 | Polar residues | ||||
Sequence: LLMSSAQASGATTVENA | ||||||
Region | 788-807 | Disordered | ||||
Sequence: RGFSGGGDDDGDVHLGHGGG | ||||||
Domain | 1132-1222 | Methyltransferase | ||||
Sequence: VVDAGAGIGDLAQWMHDSGIEYGRYVGLEGVPEMVAKGNERQLPEFSMVQADFAGDEKAFTRHSPDVVVFSGSLNTFDEEAARAVVRRAWD | ||||||
Domain | 1293-1449 | Glutamine amidotransferase | ||||
Sequence: DHGYDLDIRRLDLGAGVPADFDEVDGVVVLGGHQNVDESHPWLAPEKAFIAEAHERNLPVVGICLGAQIIADALGGTVGKMDAMEVGLADVEINASAHTDTILAGIAWDSKQFVWHGYEVKELPAGAQLLASSAACKVQAYRAGMRTYGFQYHFECD | ||||||
Region | 2299-2328 | Disordered | ||||
Sequence: HPAGGVAQDEAVETARADGERRGEGVPEGL | ||||||
Compositional bias | 2311-2328 | Basic and acidic residues | ||||
Sequence: ETARADGERRGEGVPEGL |
Sequence similarities
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,731
- Mass (Da)297,401
- Last updated2021-09-29 v1
- Checksum775A84105D7323D8
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 13-29 | Polar residues | ||||
Sequence: LLMSSAQASGATTVENA | ||||||
Compositional bias | 2311-2328 | Basic and acidic residues | ||||
Sequence: ETARADGERRGEGVPEGL |
Keywords
- Technical term