A0A812TUM1 · A0A812TUM1_9DINO

  • Protein
    branched-chain-amino-acid transaminase
  • Gene
    ilvE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Acts on leucine, isoleucine and valine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.
Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.
Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site1356Nucleophile
Active site1445
Active site1447

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmembrane
Molecular Functionbranched-chain-amino-acid transaminase activity
Molecular Functionmetalloendopeptidase activity
Biological Processbase-excision repair
Biological ProcessCAAX-box protein processing
Biological Processglutamine metabolic process
Biological Processisoleucine biosynthetic process
Biological ProcessL-leucine biosynthetic process
Biological Processvaline biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    branched-chain-amino-acid transaminase
  • EC number

Gene names

    • Name
      ilvE
    • ORF names
      SNEC2469_LOCUS15837

Organism names

Accessions

  • Primary accession
    A0A812TUM1

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane335-359Helical
Transmembrane371-393Helical
Transmembrane414-442Helical
Transmembrane462-483Helical
Transmembrane495-514Helical
Transmembrane520-538Helical
Transmembrane879-902Helical
Transmembrane922-942Helical
Transmembrane954-976Helical
Transmembrane988-1009Helical
Transmembrane1041-1068Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-29Disordered
Compositional bias13-29Polar residues
Region788-807Disordered
Domain1132-1222Methyltransferase
Domain1293-1449Glutamine amidotransferase
Region2299-2328Disordered
Compositional bias2311-2328Basic and acidic residues

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,731
  • Mass (Da)
    297,401
  • Last updated
    2021-09-29 v1
  • Checksum
    775A84105D7323D8
MDAGRHTHQKKELLMSSAQASGATTVENATATSEDRPFIWIDGKLLPKSQATVSVFDHGFLYGDGCFEGIRVYKGVIFKCQSHLDRIYRNAERLRMKMPQTPDQMREIMEETVAANELTDGYIRLIFSRGVGTLGLNPFQCPTPTVVCIADQIRLYPEEMYTKGMKIIVAKRPRTPTACLDPTLKSLNYLNNILAKVEAIDAGCLEAIMLSTDGYVGECTGDNLFIVKGGEVFTSPLEVGMLDGITRAFVMKTLCPKLGVKLTEKKLTLDDVYDADEIFLTGSAAEIIAVTQVEDKVISDGEGEVTGKLRGAFRAIVTGDDIPVAERGLSRWLDVLLVIVAVPIALMIEAIMSIVFGGYGDEGSGGVSEQVYGSLWYVTSWIPTFAILAYLMISRGESWARFGFTRFRIGVDGSVGLLCALVWFASYFFVAVVFSVSGLWMVDGWLGVYADYEAIEYATPSGWVWAIVAAGTLVSAFAEEWVFRSYLLTRMCDEGMGSARAVLCSSALFATYHIYQGVEAFVDIFVSGCLFAMVFLCLRRIWPLVIAHFLWNMWDEPRVVQVGGAGDFDVQRVALDDDDGLAQLLDQRGVVRRREVVLRVGAPEEARCEELGGLDADEVLARDGALHGAHFRVDLARVAQDGVEGVDVRVVARGLAHALDGVGDGDARDDRVVLLARLEDAVDELPAHAGAGRVVDGDVRRVLRHEGERVRDGLVAVRHAALADGDAQEAQLVAVAGEEFVVVRVVVRPGDDDRADLVAFDEELDGALENGASAQVFVELGDDAAESRGFSGGGDDDGDVHLGHGGGSTTPRVVPEGILCVGCGYELSGLPFDPESKCPECGLEIEKTKVGPLLRYESREWLERTASGLRLLHQAMRAFGVFFGLLVLMVVLVVLGMIVFLIFGWDAARSDAVALFGDVTRLAVRVGFVIALCVMIVGVYRLSRPPEVLKPEGGNWRMWMLAGPFCLIGLIVIGAIEKRGGPTIGWVRWAMSLSLVLTMVCAWVSYIAMDRVLHELDSRCAGAPALDPLPKMTADWIGRRVVVCMILAIPAFVSFSTVAGLVQLAVLIACMDILKWVRVTRERVAKELGHKSEHAVKEFGASFESTLWLSKEKQVGRFEVIAGMAPLHGRVVVDAGAGIGDLAQWMHDSGIEYGRYVGLEGVPEMVAKGNERQLPEFSMVQADFAGDEKAFTRHSPDVVVFSGSLNTFDEEAARAVVRRAWDAASEAVVFNFLSKRNGVKNPPDPSPARRFDPVAMVDWALGLTPKVRYRQDYFEGHDGTMCRPGRLGVTLRDHGYDLDIRRLDLGAGVPADFDEVDGVVVLGGHQNVDESHPWLAPEKAFIAEAHERNLPVVGICLGAQIIADALGGTVGKMDAMEVGLADVEINASAHTDTILAGIAWDSKQFVWHGYEVKELPAGAQLLASSAACKVQAYRAGMRTYGFQYHFECDRSMIGEYVEKFRSELHGTGVTSEEFANQLEAHYEMFARLADRLCLNIVTYLLPQAANIAAHETLVRPLNLDRGVAILAISQPSKKRGGDVVLKANRKLSKAESGEAKRQVRRMLSLADDGVRSFHKVDPRFKRSGRGRLFRSPTLFEDIIKTVTSCNVAWTSTIRMNERLCETINPAFPTDRQMARRKPATLRARCSVGYRDQRMVDLAKLSVRGEIDEAWYEDPATSDEDAHAALLELPGIGPYAAANVMQLLGRYSHIPCDTETVRHAKTVLGMTGTERQITKKVHEHYEPFGEHKFRSYWFELWEFYEGKRGNAWTWEPETTGKTFTAAQLKERASMRVLDMPAGSGVLSVPLKAAGFDVTPADLFPEYLAESIEGPAGETVAAYFTRRTEGTPMPADVERALFPNGAPAVDTSITATAADMEARMPFEDGSFDVVLCVEGIEHVLNRHAVLEEFRRLLKPGGKLVMTTPNLLSTRARLAYAFAGQRAFKSFIDEHSSVWGRSEDGSRLYHGHAFLVNYFQVRYSLHHCGFRLTELLRSNWSTTSVLNAWMVPLIALATKRSQRKAKRKFPLKKEDGRIPRDAVEPFDEICRHVLSGELLYNATLMTVSEAVCVALARGVQGDLAHRAPFRVVLDERSHGLGVLGCAPADEAAARVELLDEGGDVRRDDGQRGEHALHDRLREGFHGGGDEHRVHALQERRDLRCLEPFVRDDALARCFRRDLERGEVEFGSVAHALGERHEGVDRDVGSFAGVVEVAEEAESGDAVRLGGRCGRIEVAGVGDAVVDVRARAGELLEPVGDGVVDGDVRDAEVLDVVVERVAHGSVGEEGGAIEASSLVEALEAGRHPAGGVAQDEAVETARADGERRGEGVPEGLAERGGVHRLKVNAGEVLLEALLPGFVGGDGEAQAELGELSDEFQVEDLDASDGLVEPPREEAGCDEKDGFVAEFFGHAQGASGMASGMETVRESVVNLLGGVVDYAGLFPPAKLEMRPTVENYAKYVACEHEWMLGRLIVPASRLTEFEDAAKDLLPRGEEGDAWLISALVSAEAFEEGMDAIFAFNDRHAPEEEGGSGEANGLALVDVIETKAGDVAGVDAILAALPEQLEAFIEIPWEGEIRGLVAAIGGDSSGGGSAKIRTGHVDAKLIPPVEAVARFIATCASAGVPFKATAGLHHPIRAEYKLTYEPGSASAVMHGYLNVFVASAMAHARKADEAALREILKETDASRFVFDEGAVRWGDLTVSSDELVSARERFAISFGSCSFTEPTEELAQLGLLG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias13-29Polar residues
Compositional bias2311-2328Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAJNJA010025808
EMBL· GenBank· DDBJ
CAE7549768.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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