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A0A810PXE1 · A0A810PXE1_9FIRM

  • Protein
    Valine--tRNA ligase
  • Gene
    valS
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.

Catalytic activity

Features

Showing features for binding site.

1877100200300400500600700800
TypeIDPosition(s)Description
Binding site530ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionaminoacyl-tRNA editing activity
Molecular FunctionATP binding
Molecular Functionvaline-tRNA ligase activity
Biological Processvalyl-tRNA aminoacylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Valine--tRNA ligase
  • EC number
  • Alternative names
    • Valyl-tRNA synthetase
      (ValRS
      )

Gene names

    • Name
      valS
    • ORF names
      MM35RIKEN_05580

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MM35
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Eubacteriales > Oscillospiraceae > Vescimonas

Accessions

  • Primary accession
    A0A810PXE1

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain, motif, coiled coil.

Type
IDPosition(s)Description
Domain18-565Aminoacyl-tRNA synthetase class Ia
Motif46-56'HIGH' region
Motif527-531'KMSKS' region
Domain607-754Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Coiled coil809-871
Domain811-871Valyl-tRNA synthetase tRNA-binding arm

Domain

The C-terminal coiled-coil domain is crucial for aminoacylation activity.
ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    877
  • Mass (Da)
    100,612
  • Last updated
    2021-09-29 v1
  • MD5 Checksum
    4F8DFB1F2242CC2D2FCACA11DF3D9289
MRKELPKVYDPRDVEPRIYKMWMDGGCFKAEPNPDKKPFSIVMPPPNVTGQLHMGHALDSTLQDILTRFKRMQGYEALWLPGTDHAGIATQIKVEEALRKEEGLTRHDLGREKFLERVWDWKEKYGNRIVQQQMKMGASCDWDRSRFTMDEGCSRAVRETFCELYDKGLIYKGSRIINWCPHCLTALSDAEVEYTDKPGNLWYVRYPLTDGSGDIVIATTRPETMMGDTGVAVNPEDEKFKHLIGKTCILPIMNREIPIIGDEYCEIGFGTGAVKMTPAHDPNDFEVGLRHNLEVIRVIADDGTINENGGPYNGMDRYECRKAIVKDLEEQGYLIKAEPYSHNVGTCYRCHNDVEPLISAQWFVKMAPLAKEAIRVVEDGTIKFVPERFTKTYINWMENVHDWCISRQLWWGHQIPAWYCDDCGHINVSRQDPTKCEKCGSTHLTRDEDVLDTWFSSALWPFSTLGWPDTESADLKYWYPTSVMVTGYDIIFFWVARMIFSGMEQMKKEPFKTVFIHGLVRDEKGRKMSKSLGNGIDPLDMAEQYGADALRFNLITGNSPGNDMRFFVEKCEAMRNFANKIWNASRFVMMNLTIEKVELPDKLELEDKWILSKLNTLIREITDNMDAYELGVASAKIYDFIWDTYCDWYIELTKTRMNGDDPAAKLAAENVLCYVLLRILELLHPFMPFITEEIWQALPHEGKYLISAPWPVYRPEFDFRAEEQAMEAVKDAISAVRARRAEMNVPPSKKAQMIIASDHAEDYRMGEHFIKRMAYASDITVTDTAPTDLTGLVTVVTHGANVYLPLAELVDFEKELERIAKEREKAAENLARIEQKLSNEKFVSKAPEAIVNAEREKAEKARALIAKLDESAAAMRG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP023415
EMBL· GenBank· DDBJ
BCK78366.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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