A0A804HKV8 · A0A804HKV8_HUMAN

  • Protein
    Peptidylglycine alpha-amidating monooxygenase
  • Gene
    PAM
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu2+ (UniProtKB | Rhea| CHEBI:29036 )

Note: Binds 2 Cu2+ ions per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds one Zn2+ ion per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site102Cu2+ 1 (UniProtKB | ChEBI); catalytic
Binding site103Cu2+ 1 (UniProtKB | ChEBI); catalytic
Binding site167Cu2+ 1 (UniProtKB | ChEBI); catalytic
Binding site237Cu2+ 1 (UniProtKB | ChEBI); catalytic
Binding site239Cu2+ 1 (UniProtKB | ChEBI); catalytic
Binding site309Cu2+ 1 (UniProtKB | ChEBI); catalytic
Binding site410Ca2+ (UniProtKB | ChEBI); structural
Binding site423C-terminal Xaa-(2S)-2-hydroxyglycine residue (UniProtKB | ChEBI) of a protein (UniProtKB | ChEBI)
Binding site475Zn2+ (UniProtKB | ChEBI); catalytic
Binding site477Ca2+ (UniProtKB | ChEBI); structural
Binding site544C-terminal Xaa-(2S)-2-hydroxyglycine residue (UniProtKB | ChEBI) of a protein (UniProtKB | ChEBI)
Binding site580Zn2+ (UniProtKB | ChEBI); catalytic
Binding site596C-terminal Xaa-(2S)-2-hydroxyglycine residue (UniProtKB | ChEBI) of a protein (UniProtKB | ChEBI)
Binding site676Zn2+ (UniProtKB | ChEBI); catalytic
Binding site677Ca2+ (UniProtKB | ChEBI); structural

GO annotations

AspectTerm
Cellular Componenttransport vesicle membrane
Molecular Functioncopper ion binding
Molecular FunctionL-ascorbic acid binding
Molecular Functionlyase activity
Molecular Functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
Biological Processpeptide metabolic process

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Peptidylglycine alpha-amidating monooxygenase

Gene names

    • Name
      PAM

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A804HKV8

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasmic vesicle, secretory vesicle membrane
; Single-pass membrane protein

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Signal1-20UniProt
ChainPRO_503247591021-798UniProt
Disulfide bond42↔181UniProt
Disulfide bond76↔121UniProt
Disulfide bond109↔126UniProt
Disulfide bond222↔329UniProt
Disulfide bond288↔310UniProt
Disulfide bond524↔545UniProt
Disulfide bond592↔603UniProt
Glycosylation655UniProtN-linked (GlcNAc...) asparagine
Modified residue (large scale data)743PRIDEPhosphoserine
Modified residue (large scale data)754PRIDEPhosphoserine
Modified residue (large scale data)767PRIDEPhosphoserine
Modified residue (large scale data)768PRIDEPhosphothreonine
Modified residue (large scale data)771PRIDEPhosphoserine
Modified residue (large scale data)780PRIDEPhosphoserine
Modified residue (large scale data)782PRIDEPhosphoserine

Keywords

Proteomic databases

Expression

Gene expression databases

    • ENSG00000145730Expressed in cardiac muscle of right atrium and 207 other cell types or tissues

Family & Domains

Features

Showing features for domain, repeat, region.

TypeIDPosition(s)Description
Domain60-171Copper type II ascorbate-dependent monooxygenase N-terminal
Domain196-340Copper type II ascorbate-dependent monooxygenase C-terminal
Repeat460-501NHL
Repeat510-555NHL
Repeat563-607NHL
Repeat659-702NHL
Region762-798Disordered

Sequence similarities

In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    798
  • Mass (Da)
    88,744
  • Last updated
    2021-09-29 v1
  • Checksum
    3B4AEDA2D5CD7BDB
MAGRVPSLLVLLVFPSSCLAFRSPLSVFKRFKETTRPFSNECLGTTRPVVPIDSSDFALDIRMPGVTPKQSDTYFCMSMRIPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWFCDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNNKDCSGVSLHLTRLPQPLIAGMYLMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRVHTHHLGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHEHHKETEYKDKIPLLQQPKREEEEVLDQDFHMEEALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYQQIGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPGTGAIYVSDGYCNSRIVQFSPSGKFITQWGEESSGSSPLPGQFTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVREIKHSSFGRNVFAISYIPGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQEIKDSEHKLETSSGRVLGRFRGKGSGGLNLGNFFASRKGYSRKGFDRLSTEGSDQEKEDDGSESEEEYSAPLPALAPSSS

Computationally mapped potential isoform sequences

There are 18 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P19021AMD_HUMANPAM973
D6RG20D6RG20_HUMANPAM68
D6RF09D6RF09_HUMANPAM29
D6RAQ2D6RAQ2_HUMANPAM42
D6RDU2D6RDU2_HUMANPAM25
F8W8D9F8W8D9_HUMANPAM175
D6RCD5D6RCD5_HUMANPAM53
H0Y9I4H0Y9I4_HUMANPAM250
D6R961D6R961_HUMANPAM28
A0A8C8KD64A0A8C8KD64_HUMANPAM973
A0A804HI59A0A804HI59_HUMANPAM897
A0A804HIQ0A0A804HIQ0_HUMANPAM867
H7BYD9H7BYD9_HUMANPAM679
A0A804HLE0A0A804HLE0_HUMANPAM265
A0A804HLJ2A0A804HLJ2_HUMANPAM71
A0A804HK31A0A804HK31_HUMANPAM83
A0A804HJJ2A0A804HJJ2_HUMANPAM150
A0A804HKM7A0A804HKM7_HUMANPAM830

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC008501
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC008779
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC010250
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC113373
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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