A0A804HJG4 · A0A804HJG4_HUMAN
- ProteinSH3-containing GRB2-like protein 3-interacting protein 1
- GeneSGIP1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids655 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | clathrin-coated pit | |
Biological Process | clathrin-dependent endocytosis |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSH3-containing GRB2-like protein 3-interacting protein 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A804HJG4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane, clathrin-coated pit ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Modified residue (large scale data) | 95 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 161 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 162 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 172 | PRIDE | Phosphothreonine | |||
Modified residue (large scale data) | 174 | PRIDE | Phosphothreonine | |||
Modified residue (large scale data) | 239 | PRIDE | Phosphothreonine | |||
Modified residue (large scale data) | 251 | PRIDE | Phosphothreonine | |||
Modified residue (large scale data) | 257 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 266 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 273 | PRIDE | Phosphothreonine | |||
Modified residue (large scale data) | 307 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 311 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 318 | PRIDE | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Interacts with proteins essential or regulating the formation of functional clathrin-coated pits. Interacts with CANX. Interacts with AP2A1. Interacts with EPS15. Interacts with SH3GL3. Interacts with AMPH. Interacts with ITSN1 (via SH3 domains). Interacts with and REPS1.
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-27 | Basic and acidic residues | |||
Region | 1-114 | Disordered | |||
Compositional bias | 75-114 | Basic and acidic residues | |||
Region | 159-347 | Disordered | |||
Compositional bias | 218-232 | Polar residues | |||
Compositional bias | 234-252 | Pro residues | |||
Compositional bias | 277-298 | Pro residues | |||
Compositional bias | 328-347 | Polar residues | |||
Domain | 386-654 | MHD | |||
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length655
- Mass (Da)70,917
- Last updated2021-09-29 v1
- MD5 ChecksumC92727344F5C83B6AF425F65D82D7F8C
Computationally mapped potential isoform sequences
There are 24 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9BQI5 | SGIP1_HUMAN | SGIP1 | 828 | ||
F6R8P8 | F6R8P8_HUMAN | SGIP1 | 345 | ||
A0A804HI01 | A0A804HI01_HUMAN | SGIP1 | 609 | ||
A0A804HHV6 | A0A804HHV6_HUMAN | SGIP1 | 653 | ||
A0A804HHX3 | A0A804HHX3_HUMAN | SGIP1 | 461 | ||
A0A804HI53 | A0A804HI53_HUMAN | SGIP1 | 129 | ||
A0A804HIP4 | A0A804HIP4_HUMAN | SGIP1 | 162 | ||
A0A804HIL8 | A0A804HIL8_HUMAN | SGIP1 | 166 | ||
A0A804HIL9 | A0A804HIL9_HUMAN | SGIP1 | 294 | ||
A0A804HIX4 | A0A804HIX4_HUMAN | SGIP1 | 519 | ||
A0A804HJ90 | A0A804HJ90_HUMAN | SGIP1 | 343 | ||
A0A804HIU6 | A0A804HIU6_HUMAN | SGIP1 | 617 | ||
A0A804HIA5 | A0A804HIA5_HUMAN | SGIP1 | 145 | ||
A0A804HHZ7 | A0A804HHZ7_HUMAN | SGIP1 | 820 | ||
A0A804HJS7 | A0A804HJS7_HUMAN | SGIP1 | 855 | ||
A0A804HK43 | A0A804HK43_HUMAN | SGIP1 | 138 | ||
A0A804HJX5 | A0A804HJX5_HUMAN | SGIP1 | 633 | ||
A0A804HJA8 | A0A804HJA8_HUMAN | SGIP1 | 678 | ||
A0A804HJI3 | A0A804HJI3_HUMAN | SGIP1 | 642 | ||
A0A804HJJ5 | A0A804HJJ5_HUMAN | SGIP1 | 796 | ||
A0A804HL75 | A0A804HL75_HUMAN | SGIP1 | 168 | ||
A0A804HKQ5 | A0A804HKQ5_HUMAN | SGIP1 | 147 | ||
A0A804HKA0 | A0A804HKA0_HUMAN | SGIP1 | 55 | ||
A0A804HKB1 | A0A804HKB1_HUMAN | SGIP1 | 318 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-27 | Basic and acidic residues | |||
Compositional bias | 75-114 | Basic and acidic residues | |||
Compositional bias | 218-232 | Polar residues | |||
Compositional bias | 234-252 | Pro residues | |||
Compositional bias | 277-298 | Pro residues | |||
Compositional bias | 328-347 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL139147 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL354978 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL356913 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL391820 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF495974 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |