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A0A804HJG4 · A0A804HJG4_HUMAN

  • Protein
    SH3-containing GRB2-like protein 3-interacting protein 1
  • Gene
    SGIP1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

function

May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentclathrin-coated pit
Biological Processclathrin-dependent endocytosis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    SH3-containing GRB2-like protein 3-interacting protein 1
  • Alternative names
    • Endophilin-3-interacting protein

Gene names

    • Name
      SGIP1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A804HJG4

Proteomes

Organism-specific databases

Subcellular Location

Membrane, clathrin-coated pit
; Peripheral membrane protein

Keywords

Disease & Variants

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)95PRIDEPhosphoserine
Modified residue (large scale data)161PRIDEPhosphoserine
Modified residue (large scale data)162PRIDEPhosphoserine
Modified residue (large scale data)172PRIDEPhosphothreonine
Modified residue (large scale data)174PRIDEPhosphothreonine
Modified residue (large scale data)239PRIDEPhosphothreonine
Modified residue (large scale data)251PRIDEPhosphothreonine
Modified residue (large scale data)257PRIDEPhosphoserine
Modified residue (large scale data)266PRIDEPhosphoserine
Modified residue (large scale data)273PRIDEPhosphothreonine
Modified residue (large scale data)307PRIDEPhosphoserine
Modified residue (large scale data)311PRIDEPhosphoserine
Modified residue (large scale data)318PRIDEPhosphoserine

Keywords

Proteomic databases

Expression

Gene expression databases

    • ENSG00000118473Expressed in stromal cell of endometrium and 131 other cell types or tissues

Interaction

Subunit

Interacts with proteins essential or regulating the formation of functional clathrin-coated pits. Interacts with CANX. Interacts with AP2A1. Interacts with EPS15. Interacts with SH3GL3. Interacts with AMPH. Interacts with ITSN1 (via SH3 domains). Interacts with and REPS1.

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias1-27Basic and acidic residues
Region1-114Disordered
Compositional bias75-114Basic and acidic residues
Region159-347Disordered
Compositional bias218-232Polar residues
Compositional bias234-252Pro residues
Compositional bias277-298Pro residues
Compositional bias328-347Polar residues
Domain386-654MHD

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    655
  • Mass (Da)
    70,917
  • Last updated
    2021-09-29 v1
  • MD5 Checksum
    C92727344F5C83B6AF425F65D82D7F8C
MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIQPSPHEPPYNSKAECAREGGKKVSKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKKFNIKIKPLQSKDILKNAATVDELKASIGNIALSPSPVGAIKRNLSSEEVARPRRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMESPKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKPGVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVVSEDDVFYDKLPSFERRCETPAGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTTAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN

Computationally mapped potential isoform sequences

There are 24 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q9BQI5SGIP1_HUMANSGIP1828
F6R8P8F6R8P8_HUMANSGIP1345
A0A804HI01A0A804HI01_HUMANSGIP1609
A0A804HHV6A0A804HHV6_HUMANSGIP1653
A0A804HHX3A0A804HHX3_HUMANSGIP1461
A0A804HI53A0A804HI53_HUMANSGIP1129
A0A804HIP4A0A804HIP4_HUMANSGIP1162
A0A804HIL8A0A804HIL8_HUMANSGIP1166
A0A804HIL9A0A804HIL9_HUMANSGIP1294
A0A804HIX4A0A804HIX4_HUMANSGIP1519
A0A804HJ90A0A804HJ90_HUMANSGIP1343
A0A804HIU6A0A804HIU6_HUMANSGIP1617
A0A804HIA5A0A804HIA5_HUMANSGIP1145
A0A804HHZ7A0A804HHZ7_HUMANSGIP1820
A0A804HJS7A0A804HJS7_HUMANSGIP1855
A0A804HK43A0A804HK43_HUMANSGIP1138
A0A804HJX5A0A804HJX5_HUMANSGIP1633
A0A804HJA8A0A804HJA8_HUMANSGIP1678
A0A804HJI3A0A804HJI3_HUMANSGIP1642
A0A804HJJ5A0A804HJJ5_HUMANSGIP1796
A0A804HL75A0A804HL75_HUMANSGIP1168
A0A804HKQ5A0A804HKQ5_HUMANSGIP1147
A0A804HKA0A0A804HKA0_HUMANSGIP155
A0A804HKB1A0A804HKB1_HUMANSGIP1318

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-27Basic and acidic residues
Compositional bias75-114Basic and acidic residues
Compositional bias218-232Polar residues
Compositional bias234-252Pro residues
Compositional bias277-298Pro residues
Compositional bias328-347Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL139147
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL354978
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL356913
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL391820
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF495974
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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