A0A804HIT4 · A0A804HIT4_HUMAN
- ProteinPRKR-like endoplasmic reticulum kinase
- GeneEIF2AK3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids965 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 471 | ATP (UniProtKB | ChEBI) | |||
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | ATP binding | |
Molecular Function | eukaryotic translation initiation factor 2alpha kinase activity | |
Biological Process | response to endoplasmic reticulum stress | |
Biological Process | response to unfolded protein |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended namePRKR-like endoplasmic reticulum kinase
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A804HIT4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass type I membrane protein
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 18 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Modified residue (large scale data) | 404 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 410 | PRIDE | Phosphothreonine | |||
Modified residue (large scale data) | 416 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 534 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 535 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 537 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 564 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 568 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 693 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 694 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 943 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 945 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 955 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 958 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 960 | PRIDE | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length965
- Mass (Da)109,916
- Last updated2021-09-29 v1
- ChecksumF569903EAD5E681E
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9NZJ5 | E2AK3_HUMAN | EIF2AK3 | 1116 | ||
A0A804HI66 | A0A804HI66_HUMAN | EIF2AK3 | 17 | ||
A0A494BZR8 | A0A494BZR8_HUMAN | EIF2AK3 | 225 | ||
A0A804HJ50 | A0A804HJ50_HUMAN | EIF2AK3 | 859 | ||
A0A804HLC2 | A0A804HLC2_HUMAN | EIF2AK3 | 177 | ||
A0A804HJV6 | A0A804HJV6_HUMAN | EIF2AK3 | 79 | ||
A0A804HL08 | A0A804HL08_HUMAN | EIF2AK3 | 139 | ||
A0A494C186 | A0A494C186_HUMAN | EIF2AK3 | 63 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC062029 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC104134 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |