A0A803MWZ0 · A0A803MWZ0_CHEQI
- ProteinPhosphomannomutase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids292 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the interconversion of mannose-6-phosphate to mannose-1-phosphate, the precursor for the synthesis of GDP-mannose. GDP-mannose is an essential sugar nucleotide for the synthesis of D-mannose-containing cell wall polysaccharides (galactomannans and glucomannans), glycolipids, glycoproteins and the antioxidant L-ascorbate.
Catalytic activity
- alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
Cofactor
Pathway
Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 56 | Nucleophile | ||||
Sequence: D | ||||||
Binding site | 56 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 58 | Proton donor/acceptor | ||||
Sequence: D | ||||||
Binding site | 58 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 65 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 167 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 178 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 185 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 223 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 225 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 251 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 263 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 268 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: T |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | metal ion binding | |
Molecular Function | phosphomannomutase activity | |
Biological Process | GDP-mannose biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphomannomutase
- EC number
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > Caryophyllales > Chenopodiaceae > Chenopodioideae > Atripliceae > Chenopodium
Accessions
- Primary accessionA0A803MWZ0
Proteomes
Genome annotation databases
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length292
- Mass (Da)33,204
- Last updated2021-06-02 v1
- ChecksumD168E0D25429F0E6
Keywords
- Technical term