A0A803MWZ0 · A0A803MWZ0_CHEQI

Function

function

Catalyzes the interconversion of mannose-6-phosphate to mannose-1-phosphate, the precursor for the synthesis of GDP-mannose. GDP-mannose is an essential sugar nucleotide for the synthesis of D-mannose-containing cell wall polysaccharides (galactomannans and glucomannans), glycolipids, glycoproteins and the antioxidant L-ascorbate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site56Nucleophile
Binding site56Mg2+ 1 (UniProtKB | ChEBI)
Active site58Proton donor/acceptor
Binding site58Mg2+ 1 (UniProtKB | ChEBI)
Binding site65alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site167alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site178alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site185alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site223alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site225alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site251Mg2+ 1 (UniProtKB | ChEBI)
Binding site263Mg2+ 1 (UniProtKB | ChEBI)
Binding site268Mg2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmetal ion binding
Molecular Functionphosphomannomutase activity
Biological ProcessGDP-mannose biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphomannomutase
  • EC number

Organism names

  • Taxonomic identifier
  • Strain
    • cv. PI 614886
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > Caryophyllales > Chenopodiaceae > Chenopodioideae > Atripliceae > Chenopodium

Accessions

  • Primary accession
    A0A803MWZ0

Proteomes

Genome annotation databases

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the eukaryotic PMM family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    292
  • Mass (Da)
    33,204
  • Last updated
    2021-06-02 v1
  • Checksum
    D168E0D25429F0E6
MLVSSLTSCITTTRSSFSLHSCYHIFRNLTPSLSHHSGEIYCSKMAAKPSIIALFDVDGTLTAPRKEVTPEMLEFMKELRKVVPVGVVGGSDLIKISEQLGKTVINDYDYVFAENGLVAYKDGAEIGIMSLKKLLGEENIKEFINFTLKYIADLDIPIKRGTFIEFRNGMINVSPIGRNCSQEERDEFEKYDKVQKIRSTMVSILREKFGHLNLTFSIGGQISFDVFPRGWDKTYSLRYLEDFSEIHFFGDKTFEGGNDHEIFVSERTIGHTVTSPEDTRKQCTEIFLTKRE

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp