A0A803M7S8 · A0A803M7S8_CHEQI

Function

function

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentnucleolus
Molecular FunctionDNA binding
Molecular FunctionNAD binding
Molecular FunctionNAD+-protein poly-ADP-ribosyltransferase activity
Molecular Functionnucleotidyltransferase activity
Molecular Functionzinc ion binding
Biological Processdouble-strand break repair
Biological Processprotein poly-ADP-ribosylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Poly [ADP-ribose] polymerase
  • EC number

Organism names

  • Taxonomic identifier
  • Strain
    • cv. PI 614886
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > Caryophyllales > Chenopodiaceae > Chenopodioideae > Atripliceae > Chenopodium

Accessions

  • Primary accession
    A0A803M7S8

Proteomes

Genome annotation databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain8-142PARP-type
Region146-183Disordered
Compositional bias160-183Basic and acidic residues
Domain361-452BRCT
Domain481-581WGR
Domain603-721PARP alpha-helical
Domain728-953PARP catalytic

Sequence similarities

Belongs to the ARTD/PARP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    953
  • Mass (Da)
    106,753
  • Last updated
    2021-06-02 v1
  • Checksum
    63ED86472632C06B
MAAPEKPWKAEYAKSARAACRTCKNNIAKEILRFGKMVQSPHFDGFMPLACLSISELLKIAAVCGATFCASLDFFVDMHVFSDDKDLLPTEMVRISAKIDGQASRGLSWYHATCFLESYPSTFPDKLSGWQSLSSSDQASVQVAAKGKAPSAESGLGSSEKFLKDSKTRDGAKRKNAGGSDQDAKIVKTDADMMIRQCGSLTKALDSGDAALESRLEVQTRALWDLKDDLKKHVSTVELRQMLQANEQSTSGSELDLRDRCADGMMFGALERCPMCSGHLSFSGGMYKCHGFISEWSKCSYSTNQPERIKGKWKLPEETDNQYLLKWFKLQKAAKPVRILPPSASNTSDGNHSANGQLKSFKDEKLEDLRVAIAGLPKETVEDFRSKIEGAGGQVHAKIKKDTNCLVVGGGLSDQHAELKKARRMKIPIVREEYLVNCIQKQKKLPFNLYKMEATGESSSMVTVKVKGRSAVHEASGLQDSGHILEEGPSIYNTTLSLSDLSSGINSYYILQIIQDDKGQECHVFRKWGRVGNEKIGSSKIEEISKSDAIEEFKRLFLEKTGNPWEAWVHKKNFRKHPGRFFPLDIDYGVNKQAPKKNLDDSNSKLAPALKELIKMLFNVETYRAAMLEFEINLSEMPLGKLSKSNIQQGFEALTQIQNLLENTGLQPSVKESLIVDASNRFFTMIPSIHPHVIRDEDDFKSKVKMLEALQDIEIASRLVGFDADSDEPLDTKYKKLQCDMVPLSHDSEDYQLIEKYLLTTHAPTHTEWSLELEEVFSLEREGELDKFAPKREKLGNRMLLWHGSRLTNFVGILSQGLRIAPPEAPATGYMFGKGVYFADLVSKSAQYCFTDKKNPVGLMLLSEVALGKVHELKKAQYMDKPPRGKHSTKGLGKKVPDEAGFAKWRDEVVVPCGKPVDSKDKTSDLMYNEYIVYDAAQVKMQYLLKVRFRYKR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias160-183Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp