A0A803LFE7 · A0A803LFE7_CHEQI
- ProteinDeoxyhypusine hydroxylase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids309 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the hydroxylation of the N6-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Catalyzes the hydroxylation of the N6-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
Catalytic activity
- [eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O
Cofactor
Note: Binds 2 Fe2+ ions per subunit.
Pathway
Protein modification; eIF5A hypusination.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 60 | Fe cation 1 (UniProtKB | ChEBI) | |||
Binding site | 61 | Fe cation 1 (UniProtKB | ChEBI) | |||
Binding site | 93 | Fe cation 1 (UniProtKB | ChEBI) | |||
Binding site | 94 | Fe cation 1 (UniProtKB | ChEBI) | |||
Binding site | 213 | Fe cation 2 (UniProtKB | ChEBI) | |||
Binding site | 214 | Fe cation 2 (UniProtKB | ChEBI) | |||
Binding site | 246 | Fe cation 2 (UniProtKB | ChEBI) | |||
Binding site | 247 | Fe cation 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | deoxyhypusine monooxygenase activity | |
Molecular Function | metal ion binding | |
Biological Process | peptidyl-lysine modification to peptidyl-hypusine |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDeoxyhypusine hydroxylase
- EC number
- Short namesDOHH
- Alternative names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > Caryophyllales > Chenopodiaceae > Chenopodioideae > Atripliceae > Chenopodium
Accessions
- Primary accessionA0A803LFE7
Proteomes
Genome annotation databases
Structure
Sequence
- Sequence statusComplete
- Length309
- Mass (Da)33,722
- Last updated2021-06-02 v1
- ChecksumC861E72A1692EAFD
Keywords
- Technical term