A0A803LFE7 · A0A803LFE7_CHEQI

Function

function

Catalyzes the hydroxylation of the N6-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Catalyzes the hydroxylation of the N6-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 2 Fe2+ ions per subunit.

Pathway

Protein modification; eIF5A hypusination.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site60Fe cation 1 (UniProtKB | ChEBI)
Binding site61Fe cation 1 (UniProtKB | ChEBI)
Binding site93Fe cation 1 (UniProtKB | ChEBI)
Binding site94Fe cation 1 (UniProtKB | ChEBI)
Binding site213Fe cation 2 (UniProtKB | ChEBI)
Binding site214Fe cation 2 (UniProtKB | ChEBI)
Binding site246Fe cation 2 (UniProtKB | ChEBI)
Binding site247Fe cation 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functiondeoxyhypusine monooxygenase activity
Molecular Functionmetal ion binding
Biological Processpeptidyl-lysine modification to peptidyl-hypusine

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Deoxyhypusine hydroxylase
  • EC number
  • Short names
    DOHH
  • Alternative names
    • Deoxyhypusine dioxygenase
    • Deoxyhypusine monooxygenase

Organism names

  • Taxonomic identifier
  • Strain
    • cv. PI 614886
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > Caryophyllales > Chenopodiaceae > Chenopodioideae > Atripliceae > Chenopodium

Accessions

  • Primary accession
    A0A803LFE7

Proteomes

Genome annotation databases

Family & Domains

Features

Showing features for repeat.

TypeIDPosition(s)Description
Repeat74-114HEAT

Sequence similarities

Belongs to the deoxyhypusine hydroxylase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    309
  • Mass (Da)
    33,722
  • Last updated
    2021-06-02 v1
  • Checksum
    C861E72A1692EAFD
MGSFEASEETVKFLCERLVDQTQPISERFRALFSLRNLKGHLPRDALILATRDASNLLAHEAAFALGQMQDADAIPALESILNDFSLHPIVRHEAAEALGAIGLEMNVPLLKKSLVSDPAPEVRETCELALHRIEEMKYNKSEDKGPSPYLSVDPAAPSSCSSISELRDLLLDEGKGMYERYAALFALRNDGGDEAISAIVDSLGAKSALLRHEVAYVLGQMQNKVASTALIRVLKDVAEHPMVRHEAAEALGSIADEKSISLLEEFAKDPEPIVSQSCEVALSMLEFEKSGKSFEYLFMQVPVVGEAA

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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