A0A803L7E5 · A0A803L7E5_CHEQI
- ProteinS-adenosylmethionine decarboxylase proenzyme
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids376 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- S-adenosyl-L-methionine + H+ = S-adenosyl 3-(methylsulfanyl)propylamine + CO2
Cofactor
Note: Binds 1 pyruvoyl group covalently per subunit.
Pathway
Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.
Features
Showing features for binding site, site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 24 | substrate | |||
Binding site | 84 | substrate | |||
Site | 84-85 | Cleavage (non-hydrolytic); by autolysis | |||
Active site | 85 | Schiff-base intermediate with substrate; via pyruvic acid | |||
Active site | 99 | Proton donor; for catalytic activity | |||
Binding site | 242 | substrate | |||
Active site | 248 | Proton acceptor; for processing activity | |||
Active site | 261 | Proton acceptor; for processing activity | |||
Binding site | 265 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | adenosylmethionine decarboxylase activity | |
Biological Process | spermidine biosynthetic process | |
Biological Process | spermine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameS-adenosylmethionine decarboxylase proenzyme
- EC number
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > Caryophyllales > Chenopodiaceae > Chenopodioideae > Atripliceae > Chenopodium
Accessions
- Primary accessionA0A803L7E5
Proteomes
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_5042324158 | 1-84 | S-adenosylmethionine decarboxylase beta chain | ||
Modified residue | 85 | Pyruvic acid (Ser); by autocatalysis | |||
Chain | PRO_5042324157 | 85-376 | S-adenosylmethionine decarboxylase alpha chain | ||
Keywords
- PTM
Structure
Sequence
- Sequence statusComplete
- Length376
- Mass (Da)41,429
- Last updated2021-06-02 v1
- ChecksumB8C8B38F78946508
Keywords
- Technical term