A0A803L4R8 · A0A803L4R8_CHEQI

Function

function

Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

Catalytic activity

  • ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
    EC:5.6.2.1 (UniProtKB | ENZYME | Rhea)

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type I (single strand cut, ATP-independent) activity
Molecular Functionzinc ion binding
Biological ProcessDNA topological change

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase
  • EC number

Organism names

  • Taxonomic identifier
  • Strain
    • cv. PI 614886
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > Caryophyllales > Chenopodiaceae > Chenopodioideae > Atripliceae > Chenopodium

Accessions

  • Primary accession
    A0A803L4R8

Proteomes

Genome annotation databases

Subcellular Location

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain8-152Toprim
Region363-384Disordered
Domain752-767CCHC-type
Region862-895Disordered
Domain905-922CCHC-type

Sequence similarities

Belongs to the type IA topoisomerase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    925
  • Mass (Da)
    102,716
  • Last updated
    2021-06-02 v1
  • Checksum
    0E72AB158B74945D
MAGNRQIRALNVAEKPSVAKAVAGILSRNQLRVREGRSRYNKIFEFDYTIRGQPIHMLFTSVTGHLMELEFDQRYRKWHSCDPSDLYQAPVHKTVPQDKLDIKRTLQQEARGCQWLILWLDCDREGENIAFEVIEVCAEANPNLNTWRARFSALIDRDIHEAVQNLVRPNQSFAEAVDARQVLFSLLLQEIDLRIGASFTRFQTMLLKDAFNFNIATEDRSLVLSYGPCQVVPPVAVLTHPYSIGHLACIGKYKHMNRKSFGLSIVLTTQRKELQISVGCVAICLTIPVQSSSMRCVLRNQLLLWQKSYTNLVSLAILEPRLTLSRLGLICMLAIVQEQQAHPVWGTYAQRLLDPEADLWKNPGSGGHDDKAHPPIHPTKFSAGESGWSQDHNNVYELVVRHFLACVSQPAVSAETTVEIDIAGEMFSASGRVILAKNYLDVYRFESWGGSMIPTYMFGQQFTPTTLTLDSGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDANTRFSPTNLMVWGKQIGNWFPQQTLRKAVIKIMLGYLFGTDTRATYNDIYELWKPYLRSKMEDDMRAVSLGTKRKAEILASCLQEMKACFLDARVNKVKLFEAMEIFFDRTNRSGAEEQQTIGGVVRRCGLCQQADMALKRKPDGKFMVSCLAFPLCRNVVWLPGSISEATVTSNICNLCSPGCVGGCDDTLRQLTEICGTGPHNLSGTSAAVRGQTPTTTSARNMASNVQRGVCSHCGQTGHSSNDCPSQVSTSGRARSRATNHTDGMALSKLPSKIWFVGVSYAALFSCKFLFQNVVDLFLLKYNVVVKASYPALCIHFNVFLLPEIRWEDMVDGGGGVQNALHTNGRGANATTARRGGRGRGRRGGGRGSDTTFVSATGEPVSGRRCFTCGDPSHFANSCPNRGI

Keywords

Genome annotation databases

Similar Proteins

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