A0A803L1Y2 · A0A803L1Y2_CHEQI

Function

function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Allosterically activated by AMP.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site120ATP (UniProtKB | ChEBI)
Binding site183-184ATP (UniProtKB | ChEBI)
Binding site208-211ATP (UniProtKB | ChEBI)
Binding site209Mg2+ (UniProtKB | ChEBI); catalytic
Site210Important for substrate specificity; cannot use PPi as phosphoryl donor
Binding site237-239substrate
Active site239Proton acceptor
Binding site282-284substrate
Binding site338substrate
Binding site395-398substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function6-phosphofructokinase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processfructose 6-phosphate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent 6-phosphofructokinase
  • EC number
  • Short names
    ATP-PFK
    ; Phosphofructokinase
  • Alternative names
    • Phosphohexokinase

Gene names

    • Name
      PFK

Organism names

  • Taxonomic identifier
  • Strain
    • cv. PI 614886
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > Caryophyllales > Chenopodiaceae > Chenopodioideae > Atripliceae > Chenopodium

Accessions

  • Primary accession
    A0A803L1Y2

Proteomes

Genome annotation databases

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain113-419Phosphofructokinase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    474
  • Mass (Da)
    52,446
  • Last updated
    2021-06-02 v1
  • Checksum
    E0603315816AA268
MAEDKKKDVENEGGENEEIIPLEKLSLSGIKLKKVPHLRDYIPISQLKTVTNPLENNPNYHPTQGFYISPSSDILLKQILYDLSDTNQHGYGQAYHRAGPSKVVYFDPDNVKAAIVTCGGLCPGLNTVIRELVVGLSDFYGVHQIFGICSGYRGFYSCHPVLLTSKMVHNWHKQGGTALETSRGGFDLCRIVDSIQHHGFNHVYIIGGDGTMRGAVKIYEEICHRKLSVVVAGIPKTVDNDVGIIDQSFGFQTAVETAQQAINAAHVEAESAVNGIGLVKLMGRSTGHIALHATLSSRDVDCCLIPENEFFLEGEGGLFEFLERRLKENKHAVVVVAEGAGQELIPRTEEEQQQDESGNPVFKDVGVWLKSELNNWWKRDHPGELVTIKYIDPTYMVRAVPANATDNMYCTLLAHSAIHGAMAGYTGFVAGRVNGCYAYIPVKEVAVTRNVVNIKDHKWAWVRSVTNQPDFQRT

Keywords

Genome annotation databases

Similar Proteins

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