A0A803KMZ3 · A0A803KMZ3_CHEQI

Function

function

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Hydrolysis of proteins in presence of ATP.
    EC:3.4.21.53 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site, active site.

1990100200300400500600700800900
Type
IDPosition(s)Description
Binding site469-476ATP (UniProtKB | ChEBI)
Active site879
Active site938

GO annotations

AspectTerm
Cellular Componentmitochondrial matrix
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionsequence-specific DNA binding
Molecular Functionserine-type endopeptidase activity
Molecular Functionsingle-stranded DNA binding
Biological Processcellular response to oxidative stress
Biological Processchaperone-mediated protein complex assembly
Biological Processmitochondrion organization
Biological Processoxidation-dependent protein catabolic process
Biological Processprotein quality control for misfolded or incompletely synthesized proteins

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lon protease homolog, mitochondrial
  • EC number

Organism names

  • Taxonomic identifier
  • Strain
    • cv. PI 614886
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > Caryophyllales > Chenopodiaceae > Chenopodioideae > Atripliceae > Chenopodium

Accessions

  • Primary accession
    A0A803KMZ3

Proteomes

Genome annotation databases

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer or homoheptamer. Organized in a ring with a central cavity.

Family & Domains

Features

Showing features for domain, coiled coil, region, compositional bias.

Type
IDPosition(s)Description
Domain108-296Lon N-terminal
Coiled coil282-311
Region696-747Disordered
Compositional bias703-747Basic and acidic residues
Domain789-989Lon proteolytic

Sequence similarities

Belongs to the peptidase S16 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    990
  • Mass (Da)
    109,638
  • Last updated
    2021-06-02 v1
  • Checksum
    0714CCF6E1AD9650
MLKVLSYSSRFQNVLASHSRSPTIARSCAESTTPLLRVLNSLRSSNYPKPFVFRAHFCSDSSSSDGSDSVGDAGVAAKAAAAEAEDADSVSPNAILPSVFRPDECFTVLALPLPHRPLFPGFYMPVNVKDPKLLAALAESQRRQAPYAGAFLVKDEPDSDEKNIYDLKGQELLNRLHEVGTLAQISSIQGEQVILIGHRRLRITEMDLPYDKDDDVMKATSFEVISTVRDVLQRSSLWRDHVQTYTKHIGDFTYPRLADFGAAISGANKFQLQQVLEELDVLKRLQLTLELMKKEVEISKIQETIAKAIEEKISGEQRRYLLNEQLKAIKKIYCELKCLTFAPPSLSIQELGLETDDKTALSAKFRERIESSKYNIPQHVMQVIEEELTKLQLLEASSSEFNVTRNYLDWLTALPWGNYSDENFDVSHAQKILDEDHYGLSDVKERILEFIAVGKLRGTAQGKIVCLSGPPGVGKTSIGRSIARALNRKFYRFSVGGLSDVAEIKGHRRTYIGAMPGKMVQCLKSVGTANPLVLIDEIDKLGRGHAGDPASAMLELLDPEQNANFLDHYLDVPIDLSKVLFVCTANVIENIPAPLLDRMEVISIAGYITDEKLRIARDYLEKTTREACGIKPEQVELTDLALLSLIENYCREAGVRNLQKQIEKIYRKIALQLVRLGASHESSSLASDASKADCIADSSETTVQEENESKAETEVRSHEDKSDETSSDNIDFEQEHPQRCNDLLDGSKDTTEIDKAEEPEVIEKVLVDQSNLSDFVGKPVFHAERIYDQTPVGVVMGLAWTAMGGSTLYVETTHVEQGEGKGALNLTGQLGDVMKESAQIALTVSRAILLEKEPNRNFFADSKVHLHVPAGATPKDGPSAGCTMITSLLSLAMKKPVKKDLAMTGEVTLTGKILPIGGGYGEELERLEEETLGPVKEKTIAAKRSGVKTIIFPAANRRDFDELSLNVKEGLDVHFVEDYREIYDLAFSED

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias703-747Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

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