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A0A803KFV6 · A0A803KFV6_XENTR

Function

function

Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border.

Catalytic activity

  • 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = sn-glycerol 3-phosphocholine + 2 hexadecanoate + 2 H+
    This reaction proceeds in the forward direction.
  • 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+
    This reaction proceeds in the forward direction.
  • 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1,3-dihexadecanoylglycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + hexadecanoate + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + octadecanoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + hexadecanoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H+
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O = 1-octadecanoyl-sn-glycerol + (9Z,12Z)-octadecadienoate + H+
    This reaction proceeds in the forward direction.
  • 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 3-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 2-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+
    This reaction proceeds in the forward direction.
    EC:3.1.1.4 (UniProtKB | ENZYME | Rhea)
  • a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H+
    This reaction proceeds in the forward direction.
    EC:3.1.1.5 (UniProtKB | ENZYME | Rhea)
  • a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+
    This reaction proceeds in the forward direction.
    EC:3.1.1.3 (UniProtKB | ENZYME | Rhea)

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Molecular Functionphospholipase activity
Biological Processlipid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phospholipase B1, membrane-associated
  • EC number
  • Alternative names
    • Lysophospholipase
    • Phospholipase A2
    • Phospholipase B/lipase
    • Triacylglycerol lipase

Gene names

    • Name
      plb1

Organism names

Accessions

  • Primary accession
    A0A803KFV6

Organism-specific databases

Subcellular Location

Apical cell membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane1390-1416Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-22
ChainPRO_503071666723-1423Phospholipase B1, membrane-associated

Keywords

Expression

Gene expression databases

Family & Domains

Sequence similarities

Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,423
  • Mass (Da)
    158,811
  • Last updated
    2021-06-02 v1
  • MD5 Checksum
    08758C160347A754023B7B3E06D12241
MGHHLPGTLCLLFALCLCSVTGNPALKANTGDEGQNDAKYLFPCDINTNRRSDQSAASVHSLSPLDIKVLSTLRSLKLNPDGANNRLQSLEQGLQRASRDVESYMGQKLPSASRISPSPQENLLDEAKKLVESMKQRQMSFANDWKMIAIFVTAEDPCEFCNKMDHTEATIEKLERVLDYLHQELPRTFVNLVDLTELNGLYLSHSSQAELRKSCDCFRKPSNYAKTTFRFSFQVALERLVLSRQYDTREDFTVVLHPVIKMMDYGNLQTLDTSLESYEFQCSVQAGPYLSTHRNSPYESLSNMLLYEEKNAQTKVFGSNFTCTDLSPSDTIPTSVHRLRPADFKVIAALGDSITAGNGAGAAITDPLDVVTEYRGLSWSIGGDQSLGNVTTLANILRQYNPNLIGFSTGRGSHHLANANLNRAVPGAKADDMLDQSKLLVQRMKLNSKINMAEDWKLLTIFIGGNDLCGICKDPIYHSPEKYIYRIQEALDYLQAEVPRLFVNLVIILDIMPLKELYDDKRTHCPQTIMRGLCSCIVENDHNSPPLETVKLFNKKYQEMTFKLIETGKYDTKEDFAVVVQPFFEYLEMPKTPEGAPDRSYMSPDCFHFGEKGHSQAARALWQNMFEPLGQKTQDQSLAEDIGIHCPTQSDPFVKTARNSNFAYPTVAPDPTHGSKLTCADKSPSVPKPTSVHALKPADVTVVAAIGDSLTAGNGIGSKPNDVLDVLNMYRGLSWSIGGDSTLDRVTTLPNILLEFNPLLTGFSTGTGNKTLHNSYLNEAVPGAKAFNLPEQVKDLIAQMKEDRRINYNNDWKVITILIGPNDLCSSCSDANFYSTKNFIDYIQEALDLLHKEVPRAFVNLVEVMDIYPLREAVLDPRVKCPVLITKMLCPCLLNIADNSQELKIVRDFNSGYQRNTQQLIDTGRYDTKDDFTVVLQPFFRNPKIPSLPNGTPDSSFMAPDCFHLSQKSHSQMARMLWKNMLEPVGMKTDILDFAAAETLTCPTPDQPFLRTYKNSNYNYTPAQPTQPPIKNWGSDLTCQATGPSSQVPTSVHKLRPADIKVVAALGDSLTAAFGAKSSSIAELGTEYRGVSWSIGGDGTLEECTTLPNILKKFNPNIKGFSTGVGRENEMFNVAISGAKAENMASQATNLVNKMKESTVINFNEDWKVITIFIGGNDLCQFCHNRDRYSVHNHVTHVKNALDILYKEIPRVFVNLVEILEVEGLRRVKANTFGCTLLKPNLCPCFINPREGSPELYEMKRFNKDLQSQVTALADKYQDREDFTVVVQPFFKNSVLPVDKNGDVDISFFSVDCFHFTERGQSEMAKALWNSMLEPIGQKQEYNNFTNDRSNLKCPTQDKPYLFTLKNSGLPEPPETVVPVPEEKEGQVPYWSVIVGTIGGCAVGCAIVGIAMSMTYKKKMRKM

Genome annotation databases

Similar Proteins

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