A0A7Z3GZ04 · A0A7Z3GZ04_PSEFL

  • Protein
    NAD-dependent protein deacetylase
  • Gene
    cobB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site105-108NAD+ (UniProtKB | ChEBI)
Active site123Proton acceptor
Binding site131Zn2+ (UniProtKB | ChEBI)
Binding site134Zn2+ (UniProtKB | ChEBI)
Binding site182Zn2+ (UniProtKB | ChEBI)
Binding site185Zn2+ (UniProtKB | ChEBI)
Binding site223-225NAD+ (UniProtKB | ChEBI)
Binding site249-251NAD+ (UniProtKB | ChEBI)
Binding site267NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent protein lysine deacetylase activity
Molecular Functiontransferase activity
Molecular Functionzinc ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacetylase
  • EC number
  • Alternative names
    • Regulatory protein SIR2 homolog

Gene names

    • Name
      cobB
    • ORF names
      C6Y56_10770

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • G7
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A7Z3GZ04

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-279Deacetylase sirtuin-type

Sequence similarities

Belongs to the sirtuin family. Class II subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    279
  • Mass (Da)
    30,842
  • Last updated
    2021-06-02 v1
  • Checksum
    23D829077083A3EB
MLDRPFHEHLDYLQQAMADGDFMVLTGAGISTPSGIPDYRDINGVRRGRQPMMYQEFLSAPESRRRYWARAMLGWPRVRQAQPNAAHEALASLQNLGRIGGLITQNVDTLHDQAGSHDVIELHGSLHRVLCLDCGQRSERDSIQQLMETQNPYLAGVDAVQAPDGDTLLDPAFEARFQVPHCPHCEGERMKPDVVFFGENVAQPTAARAMAAAENAAGMLVVGSSLMAYSAFRLCRVIADRGKPLIAINLGKTRADELLDLKIEESCEQLLPLLAERLT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP027561
EMBL· GenBank· DDBJ
QJP95064.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp