A0A7Z3GZ04 · A0A7Z3GZ04_PSEFL
- ProteinNAD-dependent protein deacetylase
- GenecobB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids279 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
Catalytic activity
- H2O + N6-acetyl-L-lysyl-[protein] + NAD+ = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 105-108 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: QNVD | ||||||
Active site | 123 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 131 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 134 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 182 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 185 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 223-225 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GSS | ||||||
Binding site | 249-251 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: NLG | ||||||
Binding site | 267 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | NAD+ binding | |
Molecular Function | NAD-dependent protein lysine deacetylase activity | |
Molecular Function | transferase activity | |
Molecular Function | zinc ion binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD-dependent protein deacetylase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionA0A7Z3GZ04
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-279 | Deacetylase sirtuin-type | ||||
Sequence: MLDRPFHEHLDYLQQAMADGDFMVLTGAGISTPSGIPDYRDINGVRRGRQPMMYQEFLSAPESRRRYWARAMLGWPRVRQAQPNAAHEALASLQNLGRIGGLITQNVDTLHDQAGSHDVIELHGSLHRVLCLDCGQRSERDSIQQLMETQNPYLAGVDAVQAPDGDTLLDPAFEARFQVPHCPHCEGERMKPDVVFFGENVAQPTAARAMAAAENAAGMLVVGSSLMAYSAFRLCRVIADRGKPLIAINLGKTRADELLDLKIEESCEQLLPLLAERLT |
Sequence similarities
Belongs to the sirtuin family. Class II subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length279
- Mass (Da)30,842
- Last updated2021-06-02 v1
- Checksum23D829077083A3EB