A0A7Z3DVL6 · A0A7Z3DVL6_9RICK

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site.

1883100200300400500600700800
TypeIDPosition(s)Description
Binding site102ATP (UniProtKB | ChEBI)
Binding site120-124ATP (UniProtKB | ChEBI)
Binding site515ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell envelope Sec protein transport complex
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting
Biological Processprotein transport by the Sec complex

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA
  • EC number

Gene names

    • Name
      secA
    • ORF names
      GOY14_00560

Organism names

Accessions

  • Primary accession
    A0A7Z3DVL6

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Membrane
; Peripheral membrane protein
Note: Distribution is 50-50.

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-24Helical

Keywords

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-628SecA family profile
Domain104-262Helicase ATP-binding

Sequence similarities

Belongs to the SecA family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    883
  • Mass (Da)
    102,162
  • Last updated
    2021-06-02 v1
  • Checksum
    411FA15C5E3A52A7
MSDFIVLLTISFIFFIFILLLFFVKKVANRKIIKSFRKIVQQINALELEMQSLSNEELAGKTEEFKRELKNGKTLNNLLVPAFAVVREASRRFLNMRHFDVQLIGGIVLHNGMISEMKTGEGKTLVATLAAYLNSLEGKGVHIVTVNDYLAKRDAEWMGKLYNFLGVSVASITSGLTDFERKKAYSADIVYSTNNELAFDYLRDNMKFSQEDMVQRGFNYAIVDEVDSILIDEARTPLIISGPVEEKNQIYRCINKIVTKLVDSDYEIDRKGRAVFLTEDGMSQVEKLLRLYNLIPENSSLYDANNMVIIHYVDQALRAHKLFAADKDYIIKDGKVVVIDEFTGRIIEGRRYSDGLHQALEAKENLEIHRENQTLASITFQNYFRMYNKLSGMTGTAATEAEEFRDVYRLNVVKIPTNVPVKRIDVDDEIYGTEKEKFNAVLKFIKECHKRLQPILVGTVSIENSEKLSVLLRSHSLKHSVLNARYHEQEAYIISQAGVPGSITIATNMAGRGTDIQLGRNIEMLMKMELKKVKSAEEREKKYQEIVERVRKDKEIAIKAGGLCVIGTERHESRRIDDQLRGRSGRQGDPGLSKFFLSLEDDLMRIFGSDRIRGFLQKVGLKNDEAVHHPWLNKALEKAQKRVEAQNYDVRKSLLKFDNVINDQRKVIFEQRNHILGNEINDLFEIYSEVNERIIESVVQSGYYEDCIEDIIEVFYTRYGINLDKEVLTEFLDKQEALSYVNNKIQEFFAEKENYFNSQNTTDLWNRVVKQVMIMTLDYLWREHLSVLESLRQSINLRAIGQRDPLNEFKREAFLMFESMLEKWKELTVHRLAYFKLSDNQEKANRLYFIKKNSFPKISRNDKCPCNSGKKYKHCHGAITLVN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP046580
EMBL· GenBank· DDBJ
QKX00857.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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