A0A7Z3CA98 · A0A7Z3CA98_PSEFL

Function

function

Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 2 [4Fe-4S] clusters per monomer.
cob(II)alamin (UniProtKB | Rhea| CHEBI:16304 )

Pathway

tRNA modification; tRNA-queuosine biosynthesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site63cob(II)alamin (UniProtKB | ChEBI)
Active site140Proton donor
Binding site140cob(II)alamin (UniProtKB | ChEBI)
Binding site161cob(II)alamin (UniProtKB | ChEBI)
Binding site164cob(II)alamin (UniProtKB | ChEBI)
Binding site175cob(II)alamin (UniProtKB | ChEBI)
Binding site195[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site198[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site201[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site205[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site221[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site223cob(II)alamin (UniProtKB | ChEBI)
Binding site230tRNA (UniProtKB | ChEBI)
Binding site248[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site248-249cob(II)alamin (UniProtKB | ChEBI)
Binding site251[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site255[4Fe-4S] cluster 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioncobalamin binding
Molecular Functionepoxyqueuosine reductase activity
Molecular Functionmetal ion binding
Biological Processqueuosine biosynthetic process
Biological ProcesstRNA modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Epoxyqueuosine reductase
  • EC number
  • Alternative names
    • Queuosine biosynthesis protein QueG

Gene names

    • Name
      queG
    • ORF names
      C6Y56_02625

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • G7
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A7Z3CA98

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain186-2154Fe-4S ferredoxin-type

Sequence similarities

Belongs to the QueG family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    366
  • Mass (Da)
    41,123
  • Last updated
    2021-06-02 v1
  • Checksum
    5CB482E9ADCC808A
MSAITTDLPALAQSIKDWGRELGFQQVGISGLDLAEHEQHLQRWLEAGYHGEMDYMGAHGSKRSHPEELVPGTLRVVSLRMDYLPGDTQMAQLLAKPEKAYISRYALGRDYHKLIRKRVQQLADRIQSEIGPFGFRAFVDSAPVLEKAIAEQAGLGWIGKNTLVLNRKAGSYFFLSELFVDLPLPVDEPHSSEHCGRCTACLDICPTNAFVGPYVLDARRCISYLTIELKNAIPEDLRPLIGNRVFGCDDCQICCPWNRFARPSGESDFKPRHNLDNAELAELFLWDEDKFLSSTEGSPLRRAGYERWLRNLAVGLGNAPSTIPVLEALKARRDYPSELVREHVEWALEQHSRSAQAKPADTVLKP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP027561
EMBL· GenBank· DDBJ
QJP98496.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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