A0A7Z3C9J2 · A0A7Z3C9J2_PSEFL

  • Protein
    Aspartate carbamoyltransferase
  • Gene
    pyrB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.

Features

Showing features for binding site.

133450100150200250300
TypeIDPosition(s)Description
Binding site71carbamoyl phosphate (UniProtKB | ChEBI)
Binding site72carbamoyl phosphate (UniProtKB | ChEBI)
Binding site99L-aspartate (UniProtKB | ChEBI)
Binding site121carbamoyl phosphate (UniProtKB | ChEBI)
Binding site151carbamoyl phosphate (UniProtKB | ChEBI)
Binding site154carbamoyl phosphate (UniProtKB | ChEBI)
Binding site184L-aspartate (UniProtKB | ChEBI)
Binding site239L-aspartate (UniProtKB | ChEBI)
Binding site280carbamoyl phosphate (UniProtKB | ChEBI)
Binding site281carbamoyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processamino acid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartate carbamoyltransferase
  • EC number
  • Alternative names
    • Aspartate transcarbamylase
      (ATCase
      )

Gene names

    • Name
      pyrB
    • ORF names
      C6Y56_27235

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • G7
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A7Z3C9J2

Proteomes

Interaction

Subunit

Heterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain19-163Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Domain171-317Aspartate/ornithine carbamoyltransferase Asp/Orn-binding

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    334
  • Mass (Da)
    36,538
  • Last updated
    2021-06-02 v1
  • Checksum
    14B62BF63818BF22
MTPLDTKRPLQLNDQGQLRHFLSLDGLRRELLTEILDTADSFLEVGARAVKKVPLLRGKTVCNVFFENSTRTRTTFELAAQRLSADVITLNVSTSSASKGETLLDTLRNLEAMAADMFVVRHGDSGAAHFIAEHVCPQVAIINGGDGRHAHPTQGMLDMLTIRRHKGGFENLSVAIVGDILHSRVARSNMLALKTLGCQDIRVIAPKTLLPIGIEQYGVKVYTDMTEGLKDVDVVIMLRLQRERMTGGLLPSEGEFYRLFGLTTARLAGAKPDCIVMHPGPINRGVEIESAVADGPHSVILNQVTYGIAIRMAVLSMAMSGQTAQRQFEQENAQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP027561
EMBL· GenBank· DDBJ
QJP98096.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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