A0A7Z3C252 · A0A7Z3C252_PSEFL
- ProteinProbable cytosol aminopeptidase
- GenepepA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids496 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
Catalytic activity
- Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
Cofactor
Note: Binds 2 manganese ions per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 266 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 271 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 271 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 278 | |||||
Sequence: K | ||||||
Binding site | 289 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 348 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 350 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 350 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Active site | 352 | |||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | manganese ion binding | |
Molecular Function | metalloaminopeptidase activity | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable cytosol aminopeptidase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionA0A7Z3C252
Proteomes
Subcellular Location
Structure
Sequence
- Sequence statusComplete
- Length496
- Mass (Da)52,586
- Last updated2021-06-02 v1
- Checksum33D7D2A9D439E7DE