A0A7Z3C252 · A0A7Z3C252_PSEFL

  • Protein
    Probable cytosol aminopeptidase
  • Gene
    pepA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

Catalytic activity

  • Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
    EC:3.4.11.1 (UniProtKB | ENZYME | Rhea)
  • Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.
    EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site266Mn2+ 2 (UniProtKB | ChEBI)
Binding site271Mn2+ 2 (UniProtKB | ChEBI)
Binding site271Mn2+ 1 (UniProtKB | ChEBI)
Active site278
Binding site289Mn2+ 2 (UniProtKB | ChEBI)
Binding site348Mn2+ 1 (UniProtKB | ChEBI)
Binding site350Mn2+ 1 (UniProtKB | ChEBI)
Binding site350Mn2+ 2 (UniProtKB | ChEBI)
Active site352

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmanganese ion binding
Molecular Functionmetalloaminopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable cytosol aminopeptidase
  • EC number
  • Alternative names
    • Leucine aminopeptidase
      (LAP
      ) (EC:3.4.11.10
      ) . EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)
    • Leucyl aminopeptidase

Gene names

    • Name
      pepA
    • ORF names
      C6Y56_05095

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • G7
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A7Z3C252

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain346-353Cytosol aminopeptidase

Sequence similarities

Belongs to the peptidase M17 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    496
  • Mass (Da)
    52,586
  • Last updated
    2021-06-02 v1
  • Checksum
    33D7D2A9D439E7DE
MELVVKSVSPETLKTATLVVAVGEGRKLGVAAKQVDELSGGAISAVLKRGDLAGKVGQSLLLHSLPNLKAERVLLVGVGKDEELGDRPFRKIVAGILNTLKGLGGSDAVLALDEIIVKNRDSYGKTRLLAETLVDGEYTFDQFKSQKAEPRALKKITLLTIKAAQAEVQRAVNHATAISNGMAFTRNLGNLPPNICHPTFLGEQAKNLGKEFKDLKVEVLDEKKIKSLGMGSFYAVGQGSAQPPRLIVMQYNGGKKSEKPYALVGKGITFDTGGISLKPGAGMDEMKYDMGGAASVFGTLRAVLELKLPINLVCILACAENMPSGTASRPGDIVTTMSGQTVEILNTDAEGRLVLCDALTYSERFKPQAVIDIATLTGACVVALGAHTSGLLGNNDELIEQLLSAGKAADDRAWQLPLFDEYQEQLDSPFADIANIGGPKAGTITAACFLSRFTKNLNWAHLDIAGTAWTSGGKDKGATGRPVPLLTQYLLDRAKA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP027561
EMBL· GenBank· DDBJ
QJP93994.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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