A0A7Z2K7M4 · A0A7Z2K7M4_9BACI

  • Protein
    Histidinol dehydrogenase
  • Gene
    hisD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site121NAD+ (UniProtKB | ChEBI)
Binding site183NAD+ (UniProtKB | ChEBI)
Binding site206NAD+ (UniProtKB | ChEBI)
Binding site229substrate
Binding site251Zn2+ (UniProtKB | ChEBI)
Binding site251substrate
Binding site254Zn2+ (UniProtKB | ChEBI)
Binding site254substrate
Active site319Proton acceptor
Active site320Proton acceptor
Binding site320substrate
Binding site353Zn2+ (UniProtKB | ChEBI)
Binding site353substrate
Binding site407substrate
Binding site412Zn2+ (UniProtKB | ChEBI)
Binding site412substrate

GO annotations

AspectTerm
Molecular Functionhistidinol dehydrogenase activity
Molecular FunctionNAD binding
Molecular Functionzinc ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histidinol dehydrogenase
  • EC number
  • Short names
    HDH

Gene names

    • Name
      hisD
    • ORF names
      GNK04_19050

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • N1-1
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Bacillus

Accessions

  • Primary accession
    A0A7Z2K7M4

Proteomes

Family & Domains

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    424
  • Mass (Da)
    45,520
  • Last updated
    2021-06-02 v1
  • Checksum
    10D26F17FF749302
MKIVNRNEGISIKRSIEQGTEEQRQAVLSILSQVKATGDEAVKENTKKFDGADLTELRVSTEEIETAYRDLTDELITTIRQAAKNIQTFHERQRRQSWFTTAEDGTMLGQKVTPLDSVGVYVPGGKAAYPSSVLMNVIPAIAAGVQRIAMVTPPDSNGNVPSGVLVAANEVGVTEIFKVGGAQAVAALAYGTETIAPVDKIVGPGNIFVALAKREVFGIVDIDMIAGPSEIVVLADEHANPAYVAADLLSQAEHDERASAVLVTTSATLAERVQQEVKQQLVELPRAEIAATSIEDYGMIYVVDHLAEAVEAVNELAPEHLEIMVDEPMTLLGKIRHAGAIFLGPYSSEPVGDYFAGPNHVLPTNGTARFSSPLSVDDFIKKSSIISYSKEALRKNGNSIVALAKLEGLDAHARAVELRLEDLV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP046564
EMBL· GenBank· DDBJ
QHA93364.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp