A0A7Z2K7M4 · A0A7Z2K7M4_9BACI
- ProteinHistidinol dehydrogenase
- GenehisD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids424 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Catalytic activity
- H2O + L-histidinol + 2 NAD+ = 3 H+ + L-histidine + 2 NADH
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 121 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 183 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 206 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 229 | substrate | ||||
Sequence: S | ||||||
Binding site | 251 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 251 | substrate | ||||
Sequence: Q | ||||||
Binding site | 254 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 254 | substrate | ||||
Sequence: H | ||||||
Active site | 319 | Proton acceptor | ||||
Sequence: E | ||||||
Active site | 320 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 320 | substrate | ||||
Sequence: H | ||||||
Binding site | 353 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 353 | substrate | ||||
Sequence: D | ||||||
Binding site | 407 | substrate | ||||
Sequence: E | ||||||
Binding site | 412 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 412 | substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | histidinol dehydrogenase activity | |
Molecular Function | NAD binding | |
Molecular Function | zinc ion binding | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistidinol dehydrogenase
- EC number
- Short namesHDH
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Bacillus
Accessions
- Primary accessionA0A7Z2K7M4
Proteomes
Structure
Sequence
- Sequence statusComplete
- Length424
- Mass (Da)45,520
- Last updated2021-06-02 v1
- Checksum10D26F17FF749302