A0A7Z1K477 · A0A7Z1K477_9PSED

  • Protein
    Fluoride-specific ion channel FluC
  • Gene
    fluC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Activity regulation

Na+ is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site76Na+ (UniProtKB | ChEBI); structural
Binding site79Na+ (UniProtKB | ChEBI); structural

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionfluoride channel activity
Molecular Functionmetal ion binding
Biological Processcellular detoxification of fluoride

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Fluoride-specific ion channel FluC

Gene names

    • Name
      fluC
    • Synonyms
      crcB
    • ORF names
      DM05_1289

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • A2-S9
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A7Z1K477

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane33-56Helical
Transmembrane68-86Helical
Transmembrane98-119Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    124
  • Mass (Da)
    13,124
  • Last updated
    2021-06-02 v1
  • MD5 Checksum
    B85208E0DCE2FB5D33A482A2F4391DC7
MFKTILAVSAAGIAGTLLRFATGTWVSANWPKHFYAATLAVNLVGCLIIGLLYGWFLLRPEVPIEIRAGLIVGFVGGLTTFSSFSLDTLRLLESGQALVAFGYLGISVFGGLLATWAGLSLTKL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PDJN01000001
EMBL· GenBank· DDBJ
PFG70947.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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