A0A7Y9N499 · A0A7Y9N499_9SPHN

  • Protein
    Bifunctional protein FolD
  • Gene
    folD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site170-172NADP+ (UniProtKB | ChEBI)
Binding site195NADP+ (UniProtKB | ChEBI)
Binding site236NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmethenyltetrahydrofolate cyclohydrolase activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological ProcessL-histidine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processpurine nucleotide biosynthetic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein FolD

Including 2 domains:

  • Recommended name
    Methylenetetrahydrofolate dehydrogenase
  • EC number
  • Recommended name
    Methenyltetrahydrofolate cyclohydrolase
  • EC number

Gene names

    • Name
      folD
    • ORF names
      HDC29_000261

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • JAI108
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Sphingopyxis

Accessions

  • Primary accession
    A0A7Y9N499

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-121Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Domain124-290Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    309
  • Mass (Da)
    32,349
  • Last updated
    2021-06-02 v1
  • MD5 Checksum
    C7A5D2A9383A6558E0216B92FFA2865E
MVARIINGKQRAASLRQEIAIGVEHLRAQRGITPKLVAILVGDDPASALYVRRKGEQAASVGMHSESHQLGSDISQARLLALIETLNRDEAVHGILVQLPLPPHIDKAAVLRSIDPAKDIDGFHPVNVGMLASDSEAASDRIVPCTPMGCMMLLADEIASLEGLAAVVVGCSNIVGRPMAQLLLQARCTVSIAHIHTRNLPDLIARADILVSAAGAPGLIRGSWIKPGSVVIDVGINRVPGEAGQGARIVGDVCFEEARMRASAITPVPGGVGPMTIACLLENTLRAAIAQTALQGSARFRSARSSDPA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACCCJ010000001
EMBL· GenBank· DDBJ
NYF30702.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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