A0A7Y9N499 · A0A7Y9N499_9SPHN
- ProteinBifunctional protein FolD
- GenefolD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids309 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Catalytic activity
- (6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H+
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 170-172 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 195 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 236 | NADP+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | methenyltetrahydrofolate cyclohydrolase activity | |
Molecular Function | methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
Biological Process | L-histidine biosynthetic process | |
Biological Process | methionine biosynthetic process | |
Biological Process | purine nucleotide biosynthetic process | |
Biological Process | tetrahydrofolate interconversion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional protein FolD
Including 2 domains:
- Recommended nameMethylenetetrahydrofolate dehydrogenase
- EC number
- Recommended nameMethenyltetrahydrofolate cyclohydrolase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Sphingopyxis
Accessions
- Primary accessionA0A7Y9N499
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 6-121 | Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic | |||
Domain | 124-290 | Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding | |||
Sequence similarities
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length309
- Mass (Da)32,349
- Last updated2021-06-02 v1
- MD5 ChecksumC7A5D2A9383A6558E0216B92FFA2865E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JACCCJ010000001 EMBL· GenBank· DDBJ | NYF30702.1 EMBL· GenBank· DDBJ | Genomic DNA |