A0A7Y6JTZ9 · A0A7Y6JTZ9_9RICK

Function

function

Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 1/2.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site253
Binding site309ATP (UniProtKB | ChEBI)
Binding site311Mg2+ 1 (UniProtKB | ChEBI)
Active site313Proton acceptor
Binding site334substrate
Binding site335Mg2+ 2 (UniProtKB | ChEBI)
Binding site474substrate
Binding site502Mg2+ 2 (UniProtKB | ChEBI)
Binding site543-545substrate
Binding site736ATP (UniProtKB | ChEBI)
Binding site773ATP (UniProtKB | ChEBI)
Binding site776substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionphosphoribosylformylglycinamidine synthase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylformylglycinamidine synthase subunit PurL
  • EC number
  • Short names
    FGAM synthase
  • Alternative names
    • Formylglycinamide ribonucleotide amidotransferase subunit II
      (FGAR amidotransferase II
      ; FGAR-AT II
      )
    • Glutamine amidotransferase PurL
    • Phosphoribosylformylglycinamidine synthase subunit II

Gene names

    • Name
      purL
    • ORF names
      GO685_02745

Organism names

Accessions

  • Primary accession
    A0A7Y6JTZ9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain216-256Phosphoribosylformylglycinamidine synthase linker
Domain293-422PurM-like N-terminal
Domain438-586PurM-like C-terminal
Domain699-776PurM-like N-terminal
Domain821-967PurM-like C-terminal

Sequence similarities

Belongs to the FGAMS family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    986
  • Mass (Da)
    108,758
  • Last updated
    2021-06-02 v1
  • Checksum
    FC68ED8C155FA5EC
MTNIRIEVLNKCKQVGNRWLVNVYSIYIREKLPSKLHEEICGLFYNKIIQNCRYYFYNEDLEEVQYDFIEPQAEWGLEISFLPGMTDNVGNTAKQIVREYLISKGHIDEDVYIKARSSKLILGKGSIPTKDDIKQEFNPITEYCTLIYKENGNCYRRHCSKQNTPLGVIPARNAGIYGSQCRGTGMTESGTKPVNLNVSDQELEKISRNGIDGNGTLGLSLAAMKAIKDYFNKLGRDPYDIELESLAQTWSEHCKHNIFCSPIDEIKDGLYAHYIKRATREINSDICVSVFSDNAGGIIFDDDYLIVDKVETHNSPSALDPFGGAMTGALGVNRDILGFGKGAVPIMNTYYFCFAKKAKGKFYRDKERTDEILPPKYIMKEVIHGVNVAGNCSGIPTQLGSVYFDDRFCGKPLVFVGSVGIIPRNINNAPSHIKRPKNGDKIVIIGGRVGRDGIHGATFSSEALSGNSPSTVVQIGDPITQRKLSNAVIQARDLGLYNAITDNGAGGLSSSIGEMGKNGFEVDLSKVPLKNDGMAPWEIWTSESQERMTLAVPEENLPAFKQIMKKHDVEVSVIGKFNESGKAVVKCPEETVIMDMETEFLHDGNPRMHLQTKPWLSPFIQAGASRTGNPSFLEVELKEMLSRPNICSKEFIVVQYDHEVQGSSVLKPLQGKGRVCSEAVVSRPVLSSNKGVVKSQGFGSSYGEIDTYHMAACAIDTAIRNYVAAGGDINHLALLDNFCWCDAYNPERLWQLKRAAEACYDFATAFQTPFISGKDSMFNDFKGYDENGKEVMISAPPSLLISAIGVIENIENAVSLDVKMPGDLIYVLGITYDELGRSEYQLYSGMGNNNVPKVDAKSARKLYERYNLAIKDGIIASAIAPNLGGSAVALAKSLIAGGLGVEIDLSLVPVGKTQNTDIINKIIMFSESQSRILVTIAPQNQQRFEELFKGIAFSCIGKVTEEKTLNIKDILKVDLKDLGNSCRSIV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WQMP01000053
EMBL· GenBank· DDBJ
NUX01421.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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