A0A7Y6JTS2 · A0A7Y6JTS2_9RICK

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site.

1886100200300400500600700800
TypeIDPosition(s)Description
Binding site105ATP (UniProtKB | ChEBI)
Binding site123-127ATP (UniProtKB | ChEBI)
Binding site518ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell envelope Sec protein transport complex
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting
Biological Processprotein transport by the Sec complex

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA
  • EC number

Gene names

    • Name
      secA
    • ORF names
      GO685_04245

Organism names

Accessions

  • Primary accession
    A0A7Y6JTS2

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Membrane
; Peripheral membrane protein
Note: Distribution is 50-50.

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-24Helical

Keywords

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain21-631SecA family profile
Domain107-265Helicase ATP-binding

Sequence similarities

Belongs to the SecA family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    886
  • Mass (Da)
    102,122
  • Last updated
    2021-06-02 v1
  • Checksum
    DF2E64ED9DBEDBA0
MSDSTLVLTVVLIFFIFILPFLFIRKIFGSTNKKIIKSFRKIAQQINALEPEMQNLSDEELAGKTEEFKRELKDGKTLNDLLVPAFAVVREASRRFLNMRHFDVQLIGGMVLHSGMISEMKTGEGKTLVATLAAYLNSLEGKGVHVVTVNDYLAKRDTEWMSKLYNSLGVSVAFITNNLTDEERKEAYSADIVYSTNNELAFDYLRDNMKFSQEDMVQRGFNYAIVDEVDSILIDEARTPLIISGPVEENNQIYKHINKIVTKLVDSDCEVDEKGRAVFLTEDGILRVEELLRSYNLIPENSSLYDTGNMIMTHYIDQALRAHKLFTADKDYIVKDGKVVIIDEFTGRMMEDRRYSDGLHQALEAKENLEIQHENQTLASVTFQNYFRMYNKLSGMTGTAATEAEEFRDIYKLNVVKIPTNVPVKRVDVDDEIYGTEKEKFNAVLRFIEECHKRLQPVLVGTVSIENSEKLSALLRSHSLKHSVLNARYHEQEAYIIAQAGMSGGITIATNMAGRGTDIQLGGNAEMIAKVELNKIKNADEREKKYQEIVERVKKDKEIAIKAGGLCVVGTERHESRRIDDQLRGRSGRQGDPGLSKFFLSLEDDLMRIFGSDRIRSFLQRVGLKNNEAIHHPWINKALEKAQKKVEARNYDVRKSLLKFDDVINNQRRVIFKQRNHILGNEINDLFEVYSEVNESVIESIVQSGYYEDYVEDIAKEFYMRYGITLDKEDLAKFLNKQEALDYINNKVQEFFTEKERYFNSQQTTDLWNTVVRQVMIMTLDHLWREHLSILKSLRQSINLRAMGQKDPLNEFKREAFLMFESMLEKWKELTIHRLAHFKLADNQEIGNRLYPTKRDSFPKVSRNDKCPCNSGKKYKHCHGAVTVVN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WQMP01000113
EMBL· GenBank· DDBJ
NUX01678.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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