A0A7Y6DLH4 · A0A7Y6DLH4_9MICO
- ProteinATP phosphoribosyltransferase
- GenehisG
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids279 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Catalytic activity
- 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP
Cofactor
Activity regulation
Feedback inhibited by histidine.
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | ATP phosphoribosyltransferase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP phosphoribosyltransferase
- EC number
- Short namesATP-PRT ; ATP-PRTase
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Leifsonia
Accessions
- Primary accessionA0A7Y6DLH4
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 49-199 | ATP phosphoribosyltransferase catalytic | ||||
Sequence: RPRDIATYVGSGALDVGITGRDLLLDSGSPAAEIAALDFAASTFRFAGPAGVFAELSDLEGKRVATSYPGLVGAFLAENGVSTSLIKLDGAVESAVRLGVADAVADVVETGSTLRKQGLEIFGPVILESEAVLVSSPAPASGVDTLLRRLQ | ||||||
Domain | 204-275 | Histidine biosynthesis HisG C-terminal | ||||
Sequence: ARQYVLIDYNLPVALLEKAVALTPGVESPTVSPLGEPEWVAVRVMIKRDQTNHIMDDLYELGARAILVTSIH |
Sequence similarities
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length279
- Mass (Da)29,425
- Last updated2021-06-02 v1
- ChecksumEA3DDB2569D6654F