A0A7Y6AUM8 · A0A7Y6AUM8_9PSED
- ProteinThiol:disulfide interchange protein DsbD
- GenedsbD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids578 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.
Catalytic activity
- [protein]-dithiol + NAD+ = [protein]-disulfide + H+ + NADH
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | electron transfer activity | |
Molecular Function | protein-disulfide reductase (NAD(P)H) activity | |
Biological Process | cytochrome complex assembly |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameThiol:disulfide interchange protein DsbD
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionA0A7Y6AUM8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 159-192 | Helical | ||||
Sequence: ALGWSLLVFFGLGLLLAFTPCSLPMLPILAGLIV | ||||||
Transmembrane | 204-226 | Helical | ||||
Sequence: LAGSYVVSMALVYAAMGVLAALL | ||||||
Transmembrane | 238-260 | Helical | ||||
Sequence: WLLGSFAAIFVLLALPMFGYFEL | ||||||
Transmembrane | 281-311 | Helical | ||||
Sequence: SLLGAGVLGALSGLLVGPCMTAPLAGALLYI | ||||||
Transmembrane | 317-339 | Helical | ||||
Sequence: ALHGGLILFALGIGIGVPLLLLV | ||||||
Transmembrane | 351-373 | Helical | ||||
Sequence: AWMNLVKGIFGFLFLATALLLLR | ||||||
Transmembrane | 379-397 | Helical | ||||
Sequence: SLWVGLCGALLLIAAYSAW | ||||||
Transmembrane | 409-430 | Helical | ||||
Sequence: LFGASALLLGLWGSLLVIGAAG |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MRHLFLLFVLLISGVAQA | ||||||
Chain | PRO_5031633881 | 19-578 | Thiol:disulfide interchange protein DsbD | |||
Sequence: GTNPFETKPEFLPVEKAFVFTSERLESGETQLYWQITDGYYLYQKRLKFDGLPAEHQPVLPPGESHSDEFFGEQQVYRQGLELKIPAGASGKIKVSFQGCADAGLCYPPQTKVVDLVGNGAVSSTNEAPDQALASNLQQRALGWSLLVFFGLGLLLAFTPCSLPMLPILAGLIVGSGASPKRGFALAGSYVVSMALVYAAMGVLAALLGANLQALLQNPWLLGSFAAIFVLLALPMFGYFELQLPVAVRDRLENVSRNQRGGSLLGAGVLGALSGLLVGPCMTAPLAGALLYIAQSGNALHGGLILFALGIGIGVPLLLLVTIGNRFLPKPGAWMNLVKGIFGFLFLATALLLLRPVLDESLWVGLCGALLLIAAYSAWKQSDGFGRIAHLFGASALLLGLWGSLLVIGAAGGSDDLFKPLQVFRASNSAVAAVPTGHDAFTTLKDPAALQRELDAAQAQGQWVLLDYYADWCVSCKVMEKQVFGKTKVLEALGDVRLLRLDVTADNAASRELLGRYKVPGPPSLLWIGADGVERRSQRITGEVDAETFLQRWTITRDAR | ||||||
Disulfide bond | 118↔124 | Redox-active | ||||
Sequence: CADAGLC | ||||||
Disulfide bond | 491↔494 | Redox-active | ||||
Sequence: CVSC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 438-576 | Thioredoxin | ||||
Sequence: PLQVFRASNSAVAAVPTGHDAFTTLKDPAALQRELDAAQAQGQWVLLDYYADWCVSCKVMEKQVFGKTKVLEALGDVRLLRLDVTADNAASRELLGRYKVPGPPSLLWIGADGVERRSQRITGEVDAETFLQRWTITRD |
Sequence similarities
Belongs to the thioredoxin family. DsbD subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length578
- Mass (Da)61,811
- Last updated2021-06-02 v1
- ChecksumB964F55BB7FE99E8