A0A7Y5YEL5 · A0A7Y5YEL5_9PSED

  • Protein
    Phosphoribosylformylglycinamidine synthase
  • Gene
    purL
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 1/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site305-316ATP (UniProtKB | ChEBI)
Binding site384-386ATP (UniProtKB | ChEBI)
Binding site676ATP (UniProtKB | ChEBI)
Binding site677Mg2+ (UniProtKB | ChEBI)
Binding site716Mg2+ (UniProtKB | ChEBI)
Binding site720Mg2+ (UniProtKB | ChEBI)
Binding site884Mg2+ (UniProtKB | ChEBI)
Binding site886ATP (UniProtKB | ChEBI)
Active site1138Nucleophile
Active site1263
Active site1265

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionphosphoribosylformylglycinamidine synthase activity
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylformylglycinamidine synthase
  • EC number
  • Short names
    FGAM synthase
    ; FGAMS
  • Alternative names
    • Formylglycinamide ribonucleotide amidotransferase
      (FGAR amidotransferase
      ; FGAR-AT
      )

Gene names

    • Name
      purL
    • Synonyms
      purI
    • ORF names
      HNO86_01350

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C1C7
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A7Y5YEL5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain35-148Phosphoribosylformylglycinamidine synthase N-terminal
Domain169-218Phosphoribosylformylglycinamidine synthase linker
Region301-328Disordered
Domain430-587PurM-like C-terminal
Domain646-805FGAR-AT PurM-N-like
Domain839-967PurM-like C-terminal

Sequence similarities

In the N-terminal section; belongs to the FGAMS family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,298
  • Mass (Da)
    140,890
  • Last updated
    2021-06-02 v1
  • Checksum
    62010427AFD32133
MLILRGAPALSAFRHSKLLEQLSQKVSAVSGLYAEFAHFAEVTGVLTGDEQQVLARLLKYGPSVPVQEPTGRLFLVLPRFGTISPWSSKASDIARNCGLTKIQRLERGIAFYVAGQFSDAEAQLISDTLHDRMTQIVLGSLEQAAGLFSHAEPKPLTAIDLLGGGRAALEKANVELGLALAEDEIDYLVNAFVGLKRNPHDIELMMFAQANSEHCRHKIFNASWDIDGESQEKSLFGMIKNTYQMHNEGVLSAYKDNASVIVGSVAGRFFPDPETRQYGAVQEPVHILMKVETHNHPTAIAPFPGASTGSGGEIRDEGATGRGAKPKAGLTGFTVSNLQIPGFEQPWEVPYGKPERIVNALDIMIEGPLGGAAFNNEFGRPALTGYFRTFEQSITTPHGDEVRGYHKPIMLAGGMGNIREEHVQKGEIVVGSKLIVLGGPAMLIGLGGGAASSMATGTSSADLDFASVQRENPEMERRCQEVIDRCWQLGDKNPISFIHDVGAGGLSNAFPELVNDGDRGGRFELRNIPNDEPGMAPHEIWSNESQERYVLAVGPADFERFKAICERERCPFAVVGEATAEPQLTVTDSHFGNSPVDMPLEVLLGKAPRMHRSVKREAELGDDFDPSTLDIAESIERVLHHPAVASKSFLITIGDRTITGLVARDQFVGPWQVPVADVAVTATSFDVYTGEAMAMGERTPLALLDAPASGRMAIGETLTNLAASRIGKISDIKLSANWMSAAGHPGEDARLYDTVKAVGMELCPELGITIPVGKDSMSMATRWNEEGVEKTVTSPMSLIVTGFAPVTDIRQTLTPQLRMDKGTTDLILIDLGRGQNRMGASILAQVHGKLGKQAPDVDDAEDLKAFFAVIQGLNADGHLLAYHDRSDGGLLTSVVEMAFAGHCGLNLNLDSLAETSADIAAILFNEELGAVIQVRQDATPDILAQFSAAGLGDCVAVIGQPINNGEINISFNGESVFEGQRRLLQRQWSETSYQIQRLRDNADCADQEFDVLLEEDNPGLNFKLSYDVNQDVAAPYIKKGIRPQVAVLREQGVNGQVEMAAAFDRAGFNAIDVHMSDILAGRVDLNDFKGMVACGGFSYGDVLGAGEGWAKSALFNSRARDAFQGFFERTDSFTLGVCNGCQMMSNLHELIPGSEFWPHFVRNRSEQFEARVAMVQIQESNSIFLQGMAGSRMPIAIAHGEGHAEFASEEALLEADLSGCVAMRFVDNHGKVTEKYPANPNGSPRGITGLTSRDGRVTIMMPHPERVFRAVQNSWRSDDWNEDAPWMRMFRNARVWVN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABFMP010000001
EMBL· GenBank· DDBJ
NUT73681.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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