A0A7Y5Y146 · A0A7Y5Y146_9BURK
- Proteinthioredoxin-dependent peroxiredoxin
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids158 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Catalytic activity
- a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O
CHEBI:35924 + RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3= CHEBI:30879 + RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 48 | Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | thioredoxin peroxidase activity | |
Biological Process | cell redox homeostasis | |
Biological Process | cellular response to oxidative stress |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namethioredoxin-dependent peroxiredoxin
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Oxalobacteraceae > Herbaspirillum
Accessions
- Primary accessionA0A7Y5Y146
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-158 | Thioredoxin | ||||
Sequence: SLLNKTVPDFSAAMTSGKTFNLADYRGKNLVLYFYPKDNTPGCTTEGMQFRDLHPEFQAANTEIFGISRDSLKSHENFKGKLGMPFELISDPDESLCTMFDVMKMKNMYGKQVRGVERSTFVIDAAGKVVKEWRGVKVPAHVDEVLSFIKTLA |
Sequence similarities
Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length158
- Mass (Da)17,782
- Last updated2021-06-02 v1
- ChecksumD9FD1850A1DBABC1