A0A7Y5ATZ1 · A0A7Y5ATZ1_9GAMM

  • Protein
    Methylated-DNA--protein-cysteine methyltransferase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

Miscellaneous

This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site119Nucleophile; methyl group acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmethylated-DNA-[protein]-cysteine S-methyltransferase activity
Biological ProcessDNA alkylation repair
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methylated-DNA--protein-cysteine methyltransferase
  • EC number
  • Alternative names
    • 6-O-methylguanine-DNA methyltransferase
      (MGMT
      )
    • O-6-methylguanine-DNA-alkyltransferase

Gene names

    • ORF names
      HRH59_18410

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • YQF-2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Chromatiales > Chromatiaceae > Rheinheimera

Accessions

  • Primary accession
    A0A7Y5ATZ1

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-63Methylguanine DNA methyltransferase ribonuclease-like
Domain69-147Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding

Sequence similarities

Belongs to the MGMT family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    154
  • Mass (Da)
    16,377
  • Last updated
    2021-06-02 v1
  • Checksum
    1D4B61974A708E9F
MFSQFIDSPLGPVQISATDHGISAISFVTTPRLAVPSALTERAATQLLAYFAGTLTQFDLPLAAQGTTFQHQVWRELCNVPFGTTCSYGDIARAISNIKAVRAVGAANGRNPVAIVVPCHRVIGANGTLTGYAGGLDKKAWLLKHEQRPQALLC

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABSOD010000032
EMBL· GenBank· DDBJ
NRQ44517.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp