A0A7X6CZT6 · A0A7X6CZT6_9ACTN
- ProteinBifunctional (P)ppGpp synthetase/guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids796 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
Catalytic activity
- GTP + ATP = guanosine 3'-diphosphate 5'-triphosphate + AMP
Pathway
Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | hydrolase activity | |
Molecular Function | kinase activity | |
Biological Process | guanosine tetraphosphate biosynthetic process | |
Biological Process | phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces
Accessions
- Primary accessionA0A7X6CZT6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-19 | Pro residues | ||||
Sequence: RPAAPTPPPAPPAAAPAPQ | ||||||
Region | 1-33 | Disordered | ||||
Sequence: RPAAPTPPPAPPAAAPAPQPPVSGISGRSGSSN | ||||||
Domain | 98-195 | HD | ||||
Sequence: YITHPLAVTTILAELGMDPATLMAGLLHDTVEDTEYGLDTLRRDFGDQVALLVDGVTKLDKVKFGEAAQAETVRKMVVAMAKDPRVLVIKLADRLHNM | ||||||
Domain | 452-513 | TGS | ||||
Sequence: NEVFVFTPKGDVIALPAGATPVDFAYAVHTEVGHRTIGAKVNGRLVPLESTLDNGDTVEVFT | ||||||
Region | 622-645 | Disordered | ||||
Sequence: NEDVAETAPPVPASLGRRRSSGDP | ||||||
Domain | 717-791 | ACT | ||||
Sequence: AIQVEALDRSRLLSDVTRILSDQHVNILSAAVQTSRDRVAISRFTFEMGDPKHLGHVLRAVRGVEGVYDVYRVTS |
Sequence similarities
Belongs to the relA/spoT family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length796
- Mass (Da)88,173
- Last updated2021-06-02 v1
- Checksum687AC5C0338B61C0
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: R | ||||||
Compositional bias | 1-19 | Pro residues | ||||
Sequence: RPAAPTPPPAPPAAAPAPQ |
Keywords
- Technical term