A0A7X6CR36 · A0A7X6CR36_9CYAN

  • Protein
    Bifunctional pantoate ligase/cytidylate kinase
  • Gene
    panC/cmk
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Catalyzes the transfer of a phosphate group from ATP to either CMP or dCMP to form CDP or dCDP and ADP, respectively.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site32-39ATP (UniProtKB | ChEBI)
Active site39Proton donor
Binding site63(R)-pantoate (UniProtKB | ChEBI)
Binding site63beta-alanine (UniProtKB | ChEBI)
Binding site168-171ATP (UniProtKB | ChEBI)
Binding site174(R)-pantoate (UniProtKB | ChEBI)
Binding site197ATP (UniProtKB | ChEBI)
Binding site205-208ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function(d)CMP kinase activity
Molecular FunctionATP binding
Molecular Functionpantoate-beta-alanine ligase activity
Biological Processnucleobase-containing small molecule interconversion
Biological Processpantothenate biosynthetic process
Biological Processphosphorylation
Biological Processpyrimidine nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional pantoate ligase/cytidylate kinase

Including 2 domains:

  • Recommended name
    Pantothenate synthetase
  • EC number
  • Short names
    PS
  • Alternative names
    • Pantoate--beta-alanine ligase
    • Pantoate-activating enzyme
  • Recommended name
    Cytidylate kinase
  • EC number
  • Short names
    CK
  • Alternative names
    • Cytidine monophosphate kinase
      (CMP kinase
      )

Gene names

    • Name
      panC/cmk
    • ORF names
      HC942_25565

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SU_5_6
  • Taxonomic lineage
    Bacteria > Cyanobacteriota > Cyanophyceae > Oscillatoriophycideae > Oscillatoriales > Microcoleaceae > Microcoleus

Accessions

  • Primary accession
    A0A7X6CR36

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-298Pantoate--beta-alanine ligase
Region299-528Cytidylate kinase
Domain307-520Cytidylate kinase

Sequence similarities

Belongs to the cytidylate kinase family. Type 1 subfamily.
Belongs to the pantothenate synthetase family.
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.
In the N-terminal section; belongs to the pantothenate synthetase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    528
  • Mass (Da)
    57,481
  • Last updated
    2021-06-02 v1
  • MD5 Checksum
    A51A862C7459F9DA44855F8348283DAB
MQLFRTIAALRCYLNSRKSATSHLEVGLVPTMGALHAGHLSLIRRARQENTIVVVSIFVNPLQFGPKEDFQDYPRNLEQDRLLCQEAGVDVIFAPSETEMFGKSGVDRPKSEILATKPIHPSSLTQVIPPPAMTSVLCGKSRPGHFQGVATIVTKFLSLVQPTRAYFGQKDAQQVAIIRQLVADFNLPVEIVACPIVREDSGLAMSSRNQYLTAEQKQQASVLYRALQQALQAFKTGDRTAETALATVKAEVARVPAVELEYAELVNPDTLTPLEVVATAGLLAVAARVGSTRLIDNLILRNRRPIVAIDGPAGAGKSTVTRQAAGALGLFYLDTGAMYRALTWLAMKTGTPMSDAPAIAELVNLSYLEYNLDPSSFTIKINGEDVTEAIRSLEVTARVSEIAAQPAVRQFLVLQQQRCGITGGIIAEGRDIGTNVFPDAELKIFLTASVKERSRRRQLELKNTGRADIGLAELERDIALRDEKDSTREVAPLRKAADAVEIQTDGLTIAEVIDRIVGLYEEKIGSRG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAUVE010000437
EMBL· GenBank· DDBJ
NJK76741.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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