A0A7X2LQL2 · A0A7X2LQL2_9BURK

  • Protein
    L-lactate dehydrogenase
  • Gene
    ldh
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of lactate to pyruvate.
Catalyzes the reversible oxidation of malate to oxaloacetate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Activity regulation

Allosterically activated by fructose 1,6-bisphosphate (FBP).

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site7-12NAD+ (UniProtKB | ChEBI)
Binding site11NAD+ (UniProtKB | ChEBI)
Binding site32NAD+ (UniProtKB | ChEBI)
Binding site76-77NAD+ (UniProtKB | ChEBI)
Binding site79substrate
Binding site85substrate
Binding site92NAD+ (UniProtKB | ChEBI)
Binding site115-117NAD+ (UniProtKB | ChEBI)
Binding site117-120substrate
Binding site140NAD+ (UniProtKB | ChEBI)
Binding site145-148substrate
Binding site150beta-D-fructose 1,6-bisphosphate (UniProtKB | ChEBI); allosteric activator
Binding site165beta-D-fructose 1,6-bisphosphate (UniProtKB | ChEBI); allosteric activator
Active site172Proton acceptor
Binding site227substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionL-lactate dehydrogenase activity
Biological Processglycolytic process
Biological Processlactate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-lactate dehydrogenase
  • EC number
  • Short names
    L-LDH

Gene names

    • Name
      ldh
    • ORF names
      GJ700_00660

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • FT92W
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Oxalobacteraceae > Telluria group > Pseudoduganella

Accessions

  • Primary accession
    A0A7X2LQL2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue218Phosphotyrosine

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-139Lactate/malate dehydrogenase N-terminal
Domain142-304Lactate/malate dehydrogenase C-terminal

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    310
  • Mass (Da)
    32,075
  • Last updated
    2021-06-02 v1
  • Checksum
    71F93AFC93758456
MKIGIVGAGAVGGAAAFALINQGIGSEIVLVDRNAALAEAQHLDLLHATPYCHPLQVRCGGFEDLAGCALVILAAGVSQAPGETRLQLLERNAAVFRAIVPAVVRHAPDAVLLVATNPLDVMTHVALRISGLPPARVIGTGTLLDSARFRALLAGRLGVATASVHAQVLGEHGDSEVLVWSGAQVAGMPLQRFAALQGVRLDGATMADIDTGVRRAAYRIIDGKGATCYGIGAALAMLARCVLFDEKRVLTVSTHWGDIDGVPDVTLSMPVQVGAQGATFHIPPALSDTEQQALADSARVIRATLAALDY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WKJJ01000001
EMBL· GenBank· DDBJ
MRV70231.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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