A0A7X1J745 · A0A7X1J745_9ACTN
- ProteinMultifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1254 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
Catalytic activity
- N6-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H+ = N6-[(R)-S8-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2
Cofactor
Protein has several cofactor binding sites:
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | oxoglutarate dehydrogenase complex | |
Molecular Function | 2-oxoglutarate decarboxylase activity | |
Molecular Function | acyltransferase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | oxoglutarate dehydrogenase (succinyl-transferring) activity | |
Molecular Function | thiamine pyrophosphate binding | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces
Accessions
- Primary accessionA0A7X1J745
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for compositional bias, region, coiled coil, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-19 | Polar residues | |||
Region | 1-25 | Disordered | |||
Region | 67-134 | Disordered | |||
Compositional bias | 70-121 | Pro residues | |||
Coiled coil | 817-844 | ||||
Domain | 906-1099 | Transketolase-like pyrimidine-binding | |||
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,254
- Mass (Da)137,087
- Last updated2021-06-02 v1
- Checksum89C2A7149E21514F
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-19 | Polar residues | |||
Compositional bias | 70-121 | Pro residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JACMSF010000036 EMBL· GenBank· DDBJ | MBC2905441.1 EMBL· GenBank· DDBJ | Genomic DNA |