A0A7W7D269 · A0A7W7D269_9ACTN

  • Protein
    Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT
  • Gene
    murT
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site197Zn2+ (UniProtKB | ChEBI)
Binding site200Zn2+ (UniProtKB | ChEBI)
Binding site213Zn2+ (UniProtKB | ChEBI)
Binding site216Zn2+ (UniProtKB | ChEBI)
Active site333

GO annotations

AspectTerm
Molecular Functionacid-amino acid ligase activity
Molecular FunctionATP binding
Molecular Functioncarbon-nitrogen ligase activity on lipid II
Molecular Functionzinc ion binding
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT
  • EC number

Gene names

    • Name
      murT
    • ORF names
      BJ982_000158

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 45784
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Streptosporangiales > Streptosporangiaceae > Sphaerisporangium

Accessions

  • Primary accession
    A0A7W7D269

Proteomes

Interaction

Subunit

Forms a heterodimer with GatD.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain61-176Mur ligase central
Domain300-397Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal

Sequence similarities

Belongs to the MurCDEF family. MurT subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    409
  • Mass (Da)
    44,883
  • Last updated
    2021-06-02 v1
  • Checksum
    5ABAB1172E984600
MTQLPLRAQLATALGRTAATLSRVTGRGDGSVIGGRVGLMLEPDLLRKLAADRKLVLVSATNGKTTTTRLITSALQELGEVATNAFGANMPAGHVSALSQAKQAPLAVLEVDEKYLPEVLDTTGASVVVLMNLSRDQMDRAAEIWLLAQKWQRALTGKNTHVIANCDDPLVTWGASTASRVTWVSCGQPWKEDSWCCPRCGGPLDRKGDDWACRECSFRRPEPVWLLDDDAVIDSARRRWVLDLQLPGRANRANAAIALATAEAFGLPVERALPRLREVRSVAGRYTTVERDGRSLRLLLAKNPAGWLEAFEVSDPSLPIILSVNAQGPDGRDTSWLWDVDYRVLRGRPVYVTGERRLDLALRLDVAEVPFQLCDTFEQAVDPQPPGRVDVIANYTAFQRIRAEFGRAV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACHND010000001
EMBL· GenBank· DDBJ
MBB4698614.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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