A0A7W7D211 · A0A7W7D211_9ACTN

  • Protein
    NADH-quinone oxidoreductase subunit I
  • Gene
    nuoI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 2 [4Fe-4S] clusters per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site43[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site46[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site49[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site53[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site91[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site94[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site97[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site101[4Fe-4S] cluster 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioniron ion binding
Molecular FunctionNADH:ubiquinone reductase (non-electrogenic) activity
Molecular Functionquinone binding
Biological Processaerobic respiration

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-quinone oxidoreductase subunit I
  • EC number
  • Alternative names
    • NADH dehydrogenase I subunit I
    • NDH-1 subunit I

Gene names

    • Name
      nuoI
    • ORF names
      BJ982_000409

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 45784
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Streptosporangiales > Streptosporangiaceae > Sphaerisporangium

Accessions

  • Primary accession
    A0A7W7D211

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Keywords

Interaction

Subunit

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain34-634Fe-4S ferredoxin-type
Domain82-1114Fe-4S ferredoxin-type
Region155-230Disordered
Compositional bias208-230Basic and acidic residues

Sequence similarities

Belongs to the complex I 23 kDa subunit family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    230
  • Mass (Da)
    25,213
  • Last updated
    2021-06-02 v1
  • Checksum
    E503060E9606A482
MAKGLAVTLRHMLGKSVTQQYPEVRPDLPARSRGVIALVEENCTVCMLCARECPDWCIYIDSHKETTPAPEGGRPRAHNVLDRFAIDFSLCMYCGICIEVCPFDALFWSPEFEYAEYDIRDLLHEKDRLAEWVQTIPIPPAHDPNAEPPKEIAAAARPAPGRPSPAAPAAPAGRETPQTRDTPARSEATARAAVRAIRPPGALPKKPSPEGPRERAEKEPPEPSGPAEEP

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias208-230Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACHND010000001
EMBL· GenBank· DDBJ
MBB4698865.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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