A0A7W4V2F9 · A0A7W4V2F9_9MICO
- ProteinPhosphoribosylglycinamide formyltransferase
- GenepurN
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids197 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
Catalytic activity
- N1-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N2-formyl-N1-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H+
Pathway
Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 12-14 | N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI) | |||
Binding site | 64 | (6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI) | |||
Binding site | 89-92 | (6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI) | |||
Binding site | 106 | (6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI) | |||
Active site | 108 | Proton donor | |||
Site | 144 | Raises pKa of active site His | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | phosphoribosylglycinamide formyltransferase activity | |
Biological Process | 'de novo' IMP biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoribosylglycinamide formyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Microbacterium
Accessions
- Primary accessionA0A7W4V2F9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Sequence
- Sequence statusComplete
- Length197
- Mass (Da)20,961
- Last updated2021-06-02 v1
- Checksum326F40EBB76FCAF5
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JACHWQ010000002 EMBL· GenBank· DDBJ | MBB2975646.1 EMBL· GenBank· DDBJ | Genomic DNA |